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Using Cross-Dressing to Enhance Anti-Tumor Immune Responses

Technology / Case number: #21679
Stefani Spranger / Ellen Duong
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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PROTAC Derivatives with Functional Handles for Chemical Conjugation/Modification

Technology / Case number: #20788J
Jeremiah A. Johnson / Aiden Wang / Michael Agius / Irene Ghobrial / Alexandre Detappe / Hung Nguyen / Yivan Jiang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Immunostimulatory Nanoparticle Adjuvants

Technology / Case number: #20798HJ
Darrell J Irvine / Shane Crotty / Yu Kato / Murillo Silva
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Use of Choline Supplementation as Therapy for APOE4-Related Disorders

Technology / Case number: #20957WPJ
Li-Huei Tsai / Greg Sienski / Priyanka Narayan / Julia Bonner / Yuan-Ta Lin
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Circular, Strained Zymogen

Technology / Case number: #21110J
Ronald T Raines / Ian Windsor
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Novel Chimeric Antigen Receptor Signaling Domains Derived via Activity-based Directed Evolution

Technology / Case number: #21116
Michael Birnbaum / Taeyoon Kyung
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Single-Dose Combination Immunotherapy Augments Responses to Checkpoint Blockades for the Treatment of Cancer

Technology / Case number: #21150H
Darrell J Irvine / Chensu Wang / Karl Dane Wittrup
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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A Ribonucleoprotein Approach to Boost the STING Signaling for Cancer Immunotherapy

Technology / Case number: #21216
Paula Hammond / Yanpu He / Jiahe Li
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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MicroRNA-based Logic Gates that Do Not Use Exogenous Proteins

Technology / Case number: #21334
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Uses of Amphiphiles in Immune Cell Therapy and Compositions Therefore

Technology / Case number: #21411H
Darrell J Irvine / Peter DeMuth
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Darrell J Irvine / Masanori Okaniwa / Eric Dane
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Miniature Stochastic NMR

Technology / Case number: #21449
Ian Hunter / Ashley Raynal (formerly Raynal)
Technology Areas: Agriculture & Food / Sensing & Imaging
Impact Areas: Sustainable Future
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Synthesis of Potent Epidithiodiketopiperazines Designed for Facile Derivatization

Technology / Case number: #21469
Mo Movassaghi / Tony Scott / Chase Olsson / Jaime Cheah / Joshua Payette
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Gene Therapy in Mammalian Cells by the use of the Strand Displacement Reaction

Technology / Case number: #21486
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Intra-Tumoral Injection of Cytotoxic Chemotherapy-Treated Tumor Cells in Combination with Systemic Immune Checkpoint Blockade for Cancer Treatment

Technology / Case number: #21498H
Darrell J Irvine / Lauren Milling / Ganapathy Sriram / Michael Yaffe
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Silk Materials to Deliver PGPR

Technology / Case number: #21588
Benedetto Marelli / Augustine Zvinavashe
Technology Areas: Agriculture & Food / Chemicals & Materials
Impact Areas: Sustainable Future, Advanced Materials
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Anti-Human KLRB1 Monoclonal Antibodies and Uses Thereof

Technology / Case number: #21645J
Karl Dane Wittrup / Nathan Mathewson / Byong Ha Kang / Kai Wucherpfennig
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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An Electrokinetic-based High-Throughput Concentrator for Cells, Bioparticles, and Molecules

Technology / Case number: #21685
Jongyoon Han / Hyuckjin Kwon
Technology Areas: Agriculture & Food / Biotechnology / Diagnostics
Impact Areas: Healthy Living
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Accurate Genome Editing

Technology / Case number: #21848
Timothy K Lu / Shota Nakade
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Precision Delivery of Multi-Scale Payloads to Tissue-Specific Targets in Plants

Technology / Case number: #22192
Benedetto Marelli / Yunteng Cao
Technology Areas: Agriculture & Food / Chemicals & Materials
Impact Areas: Sustainable Future
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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