PROTAC Derivatives with Functional Handles for Chemical Conjugation/Modification
Invention type: Technology
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Case number: #20788J
Disclosed multifunctional compounds, conjugates, macromolecules, and polymers that target dysregulated proteins for degradation. Also disclosed are methods of preparation, compositions, kits, and methods of use relating to the degraders.
Researchers
Jeremiah A. Johnson
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Aiden Wang
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Michael Agius
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Irene Ghobrial
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Alexandre Detappe
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Hung Nguyen
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Yivan Jiang
Departments: Department of Chemistry, Chemistry
Technology Areas: Chemicals & Materials: Catalysis & Synthesis, Polymers / Therapeutics: Small Molecules
Impact Areas: Healthy Living
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proteolysis targeting chimeric molecules (protacs) with functional handles and uses thereof
United States of America | Granted | 12,042,513
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