Gene Therapy in Mammalian Cells by the use of the Strand Displacement Reaction
Invention type: Technology
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Case number: #21486
The present disclosure, at least in part, relates to an engineered RNA (e.g., microRNA and sgRNA), in the absence of an input signal, that is engineered to have a large enough energy gap between the formations of a first secondary structure, which is unrecognizable by an actuator, and a second secondary structure, which is recognizable by an actuator (e.g., Drosha and Cas protein).
Researchers
Departments: Department of Biological Engineering
Technology Areas: Biotechnology: DNA & RNA Editing, Synthetic Biology / Therapeutics: Nucleic Acids
Impact Areas: Healthy Living
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trans-activated functional rna by strand displacement and uses thereof
United States of America | Granted | 11,834,659
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