Single-Dose Combination Immunotherapy Augments Responses to Checkpoint Blockades for the Treatment of Cancer
Invention type: Technology
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Case number: #21150H
The present disclosure provides a method of treating cancer with a priming dose of combination immunotherapy comprising IL-2 (e.g., extended-PK IL-2), an immune checkpoint inhibitor, a tumor targeting antibody or integrin-binding polypeptide, and optional cancer vaccine, administered prior to maintenance doses of immune checkpoint inhibitor therapy. The methods of the disclosure can be used to treat a broad range of cancer types.
Researchers
Darrell J Irvine
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Chensu Wang
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Karl Dane Wittrup
Departments: Department of Chemical Engineering
Technology Areas: Therapeutics: Proteins & Antibodies, Vaccines
Impact Areas: Healthy Living
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combination immunotherapy dosing regimen for immune checkpoint blockade
United States of America | Granted | 12,295,986 -
combination immunotherapy dosing regimen for immune checkpoint blockade
United States of America | Granted | 11,235,032 -
single-dose combination immunotherapy augments responses to checkpoint blockades for the treatment of cancer
European Patent Convention | Published application
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