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Self Actuating Systems for Retention and Electrical Stimulation in the Gastrointestinal Tract

Technology / Case number: #20292JQ
Robert Langer / David Dellal / Ester Caffarel Salvador / Niclas Roxhed / Minsoo Khang / Alex Abramson / Taylor Bensel / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Solid Formulations with Ultra-High Drug Loading

Technology / Case number: #19446J
Robert Langer / Ester Caffarel Salvador / Niclas Roxhed / Minsoo Khang / Alex Abramson / Taylor Bensel / Giovanni Traverso
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Multi-Pronged Self-Orienting Millimeter-Scale Actuator for Drug Delivery

Technology / Case number: #21169JQ
Robert Langer / Jacob Wainer / Michael Williams / Alex Abramson / Giovanni Traverso
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Injectable, Thermogelling, Prolonged-Release Hydrogel Formulations for CPG-ODNs

Technology / Case number: #26051J
Robert Langer / Stephen Linderman / Eric Wehrenberg-Klee / Jan-Georg Rosenboom / Avik Som / Ameya Kirtane / Giovanni Traverso
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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mRNA-based Myeloid Cell Stimulation Enhances Therapeutic Efficacy

Technology / Case number: #25731J
Daniel Anderson / Christopher Garris / Riddha Das / Kaelan Reed / Akash Gupta / Ralph Weissleder
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Self-Righting Systems, Methods, and Related Components

Technology / Case number: #20706JQ
Robert Langer / Ester Caffarel Salvador / Niclas Roxhed / Minsoo Khang / Alex Abramson / Taylor Bensel / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Triggerable Shape Memory Gastric Devices for Drug Delivery

Technology / Case number: #17860
Robert Langer / Yida Zhao / Shiyi Zhang / Giovanni Traverso
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Self-Assembling Drug Delivery Devices For Gastrointestinal Retention

Technology / Case number: #17002J
Robert Langer / Jiaqi Lin / Stacy Mo / Angela Diciccio / William Gates / Boris Nikolic / Phillip Eckhoff / Dean Glettig / Shiyi Zhang / Andrew Bellinger / Lowell Wood / Giovanni Traverso
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Delivery Systems for Anti-Retroviral Drugs

Technology / Case number: #18813J
Robert Langer / Omar Abouzid / Ameya Kirtane / Mousa Jafari / Tyler Grant / Stacy Mo / Angela Diciccio / Dean Glettig / Shiyi Zhang / Andrew Bellinger / Giovanni Traverso
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Using Gamma Sensory Entriainment to Rescue Brain Development Defects in Down Syndrome

Technology / Case number: #26448P
Li-Huei Tsai / Md Rezaul Islam / Dong Shin Park
Technology Areas: Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Rational Mutants of Bxb1 Derived from Structural Insights

Technology / Case number: #25675J
Omar Abudayyeh / Teppei Soma / Masahiro Hiraizumi / Christopher Fell / Hiroshi Nishimasu / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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L-SOMA: Oral Delivery of a Biologic Molecule to the Stomach Wall via a Liquid Injection

Technology / Case number: #21194QJ
Robert Langer / Andreas Vegge / Jorrit Jeroen Water / Xiaoya Lu / Mikkel Wennemoes Hvitfeld Ley / Brian Jensen / Mette Poulsen / Jesper Windum / Brian Mouridsen / Mikkel Oliver Jespersen / Morten Frederiksen / Alex Abramson / Giovanni Traverso
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Apparatus, Systems and Methods For Continuous RNA Manufacturing

Technology / Case number: #26430J
Allan S. Myerson / Marianna Sofman / Richard D Braatz
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Peptide-Polyanion Conjugate to Activate STING Innate Immune Signaling

Technology / Case number: #26286
Paula Hammond / Justin Kaskow
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Devices for Needless Drug Delivery in the GI tract

Technology / Case number: #21911QJ
Robert Langer / Adam Jun Bohr / Aghiad Ghazal / Drago Sticker / Cody Cleveland / Torben Sebastia Last / Yi Lu / Graham Arrick / Declan Gwynne / Sean You / Jacob Wainer / Niclas Roxhed / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Supramolecular PEGylation of Protein Therapeutics

Technology / Case number: #18077
Robert Langer / Eric Appel / Matthew Webber / Daniel Anderson
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Engineered Binding Proteins that Specifically Target Bacteria

Technology / Case number: #22368
Hadley Sikes / Yining Hao / Ki-Joo Sung
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Collapsible Library Design to Enable Characterization of Hyperdiverse Peptide Libraries

Technology / Case number: #26377J
Bradley L. Pentelute / Dimuthu Vithanage / Corey Johnson / John Albin / Gha Young Lee / Wayne Vuong
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Precision Administration of Ultra-Loaded Injectable Nanocarriers (PAULINA)

Technology / Case number: #26169J
Giovanni Traverso / Cooper Konz / Yogesh Deshpande / Nabil Shalabi / Will Tritschler / SeungHo Lee / Jason Li
Technology Areas: Drug Delivery
Impact Areas: Healthy Living
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Fanzors are RNA-Guided Nucleases Encoded in Eukaryotic Genomes

Technology / Case number: #24942
Omar Abudayyeh / Kaiyi Jiang / Justin Lim / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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