Specific Viral Targeting of Hematopoietic Stem Cells via Engineering of Viral Tropism
Exclusively Licensed
Invention type: Technology
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Case number: #22988JQ
Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery to a hematopoietic stem cell (HSC), wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.
Researchers
Michael Birnbaum
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Cassandra Burnett
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Kole Roybal
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Stephanie Gaglione
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Connor Dobson
Departments: Department of Biological Engineering, David H Koch Institute for Integrative Cancer Res
Technology Areas: Biotechnology: DNA & RNA Editing, Synthetic Biology / Drug Delivery: Vectors & Virus like Particles / Therapeutics: Cell Based Therapy, Nucleic Acids
Impact Areas: Healthy Living
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viral targeting of hematopoietic stem cells
Singapore | Pending -
viral targeting of hematopoietic stem cells
United States of America | Published application -
viral targeting of hematopoietic stem cells
Hong Kong | Published application -
viral targeting of hematopoietic stem cells
Australia | Pending -
viral targeting of hematopoietic stem cells
Brazil | Pending -
viral targeting of hematopoietic stem cells
Canada | Published application -
viral targeting of hematopoietic stem cells
China | Published application -
viral targeting of hematopoietic stem cells
Eurasian Patent Organization | Published application -
viral targeting of hematopoietic stem cells
European Patent Convention | Published application -
viral targeting of hematopoietic stem cells
Israel | Pending -
viral targeting of hematopoietic stem cells
India | Pending -
viral targeting of hematopoietic stem cells
Japan | Published application -
viral targeting of hematopoietic stem cells
Korea (south) | Published application -
viral targeting of hematopoietic stem cells
Mexico | Published application -
viral targeting of hematopoietic stem cells
New Zealand | Pending
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