Vaccine Formulation Containing Dynamically Stabilized Immunostimulatory Oligonucleotide Micelles
Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. Depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. The conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.
Researchers
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immunostimulatory compositions and methods of use thereof
United States of America | Pending -
immunostimulatory compositions and methods of use thereof
United States of America | Granted | 9,107,904 -
immunostimulatory compositions and methods of use thereof
United States of America | Granted | 10,029,016 -
immunostimulatory compositions and methods of use thereof
Hong Kong | Granted | 1,207,001 -
immunostimulatory compositions and methods of use thereof
Belgium | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
Switzerland | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
Germany | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
Spain | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
France | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
United Kingdom | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
Ireland | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
Italy | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
Luxembourg | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
Netherlands | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
Norway | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
United States of America | Granted | 10,953,105 -
immunostimulatory compositions and methods of use thereof
Japan | Granted | 6,375,289 -
immunostimulatory compositions and methods of use thereof
European Patent Convention | Granted | 2,833,918 -
immunostimulatory compositions and methods of use thereof
Japan | Published application -
immunostimulatory compositions and methods of use thereof
European Patent Convention | Published application -
immunostimulatory compositions and methods of use thereof
Japan | Granted | 7,631,277 -
immunostimulatory compositions and methods of use thereof
Japan | Published application -
vaccine formulation containing dynamically stabilized immunostimulatory oligonucleotide micelles
Hong Kong | Published application -
immunostimulatory compositions and methods of use thereof
United States of America | Granted | 12,303,566 -
immunostimulatory compositions and methods of use thereof
Japan | Published application
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