Vaccine Formulation Containing Dynamically Stabilized Immunostimulatory Oligonucleotide Micelles

Exclusively Licensed

Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. Depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. The conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.

Researchers

Darrell J Irvine / Haipeng Liu

Departments: David H Koch Institute for Integrative Cancer Res
Technology Areas: Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Nucleic Acids, Vaccines
Impact Areas: Healthy Living

  • immunostimulatory compositions and methods of use thereof
    United States of America | Pending
  • immunostimulatory compositions and methods of use thereof
    United States of America | Granted | 9,107,904
  • immunostimulatory compositions and methods of use thereof
    United States of America | Granted | 10,029,016
  • immunostimulatory compositions and methods of use thereof
    Hong Kong | Granted | 1,207,001
  • immunostimulatory compositions and methods of use thereof
    Belgium | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    Switzerland | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    Germany | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    Spain | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    France | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    United Kingdom | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    Ireland | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    Italy | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    Luxembourg | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    Netherlands | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    Norway | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    United States of America | Granted | 10,953,105
  • immunostimulatory compositions and methods of use thereof
    Japan | Granted | 6,375,289
  • immunostimulatory compositions and methods of use thereof
    European Patent Convention | Granted | 2,833,918
  • immunostimulatory compositions and methods of use thereof
    Japan | Published application
  • immunostimulatory compositions and methods of use thereof
    European Patent Convention | Published application
  • immunostimulatory compositions and methods of use thereof
    Japan | Granted | 7,631,277
  • immunostimulatory compositions and methods of use thereof
    Japan | Published application
  • vaccine formulation containing dynamically stabilized immunostimulatory oligonucleotide micelles
    Hong Kong | Published application
  • immunostimulatory compositions and methods of use thereof
    United States of America | Granted | 12,303,566
  • immunostimulatory compositions and methods of use thereof
    Japan | Published application

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