Novel Memory-like NK Cell Based Chimeric Antigen Receptor (CAR) Targeting Mutated NPM1 in Myeloid Malignancies
Exclusively Licensed
Invention type: Technology
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Case number: #22960J
The present disclosure relates to cytokine-induced memory-like NK cells expressing a chimeric antigen receptor polypeptide that binds to a neoepitope of mutant nucleophosmin (NPM1c) in complex with, or presented by, a class I major histocompatibility complex (MHC class I) protein, or cells expressing such compounds, and their use in methods for treating, or ameliorating one or more symptoms of, cancer.
Researchers
Jianzhu Chen
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James Ham
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Han Dong
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Jerome Ritz
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Rizwan Romee
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Guozhu Xie
Departments: Department of Biology
Technology Areas: Biotechnology: DNA & RNA Editing, Synthetic Biology / Drug Discovery and Research Tools: Cell Interrogation, Genomics & Proteomics / Therapeutics: Cell Based Therapy, Proteins & Antibodies
Impact Areas: Healthy Living
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methods for generating engineered memory-like nk cells and compositions thereof
United States of America | Published application -
methods for generating engineered memory-like nk cells and compositions thereof
Hong Kong | Pending -
methods for generating engineered memory-like nk cells and compositions thereof
Hong Kong | Pending -
methods for generating engineered memory-like nk cells and compositions thereof
Korea (south) | Published application -
methods for generating engineered memory-like nk cells and compositions thereof
Japan | Published application -
methods for generating engineered memory-like nk cells and compositions thereof
Australia | Pending -
methods for generating engineered memory-like nk cells and compositions thereof
Canada | Published application -
methods for generating engineered memory-like nk cells and compositions thereof
European Patent Convention | Published application -
methods for generating engineered memory-like nk cells and compositions thereof
Japan | Published application -
methods for generating engineered memory-like nk cells and compositions thereof
Korea (south) | Published application -
methods for generating engineered memory-like nk cells and compositions thereof
China | Published application -
methods for generating engineered memory-like nk cells and compositions thereof
India | Published application -
methods for generating engineered memory-like nk cells and compositions thereof
Israel | Pending -
methods for generating engineered memory-like nk cells and compositions thereof
Mexico | Pending -
methods for generating engineered memory-like nk cells and compositions thereof
Brazil | Pending -
methods for generating engineered memory-like nk cells and compositions thereof
Singapore | Pending
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