Novel Memory-like NK Cell Based Chimeric Antigen Receptor (CAR) Targeting Mutated NPM1 in Myeloid Malignancies

Exclusively Licensed

The present disclosure relates to cytokine-induced memory-like NK cells expressing a chimeric antigen receptor polypeptide that binds to a neoepitope of mutant nucleophosmin (NPM1c) in complex with, or presented by, a class I major histocompatibility complex (MHC class I) protein, or cells expressing such compounds, and their use in methods for treating, or ameliorating one or more symptoms of, cancer.

Researchers

Jianzhu Chen / James Ham / Han Dong / Jerome Ritz / Rizwan Romee / Guozhu Xie

Departments: Department of Biology
Technology Areas: Biotechnology: DNA & RNA Editing, Synthetic Biology / Drug Discovery and Research Tools: Cell Interrogation, Genomics & Proteomics / Therapeutics: Cell Based Therapy, Proteins & Antibodies
Impact Areas: Healthy Living

  • methods for generating engineered memory-like nk cells and compositions thereof
    United States of America | Published application
  • methods for generating engineered memory-like nk cells and compositions thereof
    Hong Kong | Pending
  • methods for generating engineered memory-like nk cells and compositions thereof
    Hong Kong | Pending
  • methods for generating engineered memory-like nk cells and compositions thereof
    Korea (south) | Published application
  • methods for generating engineered memory-like nk cells and compositions thereof
    Japan | Published application
  • methods for generating engineered memory-like nk cells and compositions thereof
    Australia | Pending
  • methods for generating engineered memory-like nk cells and compositions thereof
    Canada | Published application
  • methods for generating engineered memory-like nk cells and compositions thereof
    European Patent Convention | Published application
  • methods for generating engineered memory-like nk cells and compositions thereof
    Japan | Published application
  • methods for generating engineered memory-like nk cells and compositions thereof
    Korea (south) | Published application
  • methods for generating engineered memory-like nk cells and compositions thereof
    China | Published application
  • methods for generating engineered memory-like nk cells and compositions thereof
    India | Published application
  • methods for generating engineered memory-like nk cells and compositions thereof
    Israel | Pending
  • methods for generating engineered memory-like nk cells and compositions thereof
    Mexico | Pending
  • methods for generating engineered memory-like nk cells and compositions thereof
    Brazil | Pending
  • methods for generating engineered memory-like nk cells and compositions thereof
    Singapore | Pending

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