Novel Memory-like NK Cell Based Chimeric Antigen Receptor (CAR) Targeting Mutated NPM1 in Myeloid Malignancies
                                                                                        
                                    Exclusively Licensed
                                
                            
                            
                            
                                                    
                    
                    
                                                                            Invention type: Technology
                                    
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                                                                            Case number: #22960J
                                                                    
                                The present disclosure relates to cytokine-induced memory-like NK cells expressing a chimeric antigen receptor polypeptide that binds to a neoepitope of mutant nucleophosmin (NPM1c) in complex with, or presented by, a class I major histocompatibility complex (MHC class I) protein, or cells expressing such compounds, and their use in methods for treating, or ameliorating one or more symptoms of, cancer.
Researchers
                            
    
    Jianzhu Chen
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    James Ham
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    Han Dong
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    Jerome Ritz
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    Rizwan Romee
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    Guozhu Xie
                        
                    
                                        Departments: Department of Biology
                                    
                                
                                                                    
                                        Technology Areas: 	Biotechnology: DNA & RNA Editing, Synthetic Biology  / Drug Discovery and Research Tools: Cell Interrogation, Genomics & Proteomics  / Therapeutics: Cell Based Therapy, Proteins & Antibodies 
                                    
                                
                                                                    
                                        Impact Areas: Healthy Living
                                    
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            methods for generating engineered memory-like nk cells and compositions thereof
 United States of America | Published application
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            methods for generating engineered memory-like nk cells and compositions thereof
 Hong Kong | Pending
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            methods for generating engineered memory-like nk cells and compositions thereof
 Hong Kong | Pending
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            methods for generating engineered memory-like nk cells and compositions thereof
 Korea (south) | Published application
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            methods for generating engineered memory-like nk cells and compositions thereof
 Japan | Published application
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            methods for generating engineered memory-like nk cells and compositions thereof
 Australia | Pending
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            methods for generating engineered memory-like nk cells and compositions thereof
 Canada | Published application
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            methods for generating engineered memory-like nk cells and compositions thereof
 European Patent Convention | Published application
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            methods for generating engineered memory-like nk cells and compositions thereof
 Japan | Published application
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            methods for generating engineered memory-like nk cells and compositions thereof
 Korea (south) | Published application
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            methods for generating engineered memory-like nk cells and compositions thereof
 China | Published application
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            methods for generating engineered memory-like nk cells and compositions thereof
 India | Published application
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            methods for generating engineered memory-like nk cells and compositions thereof
 Israel | Pending
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            methods for generating engineered memory-like nk cells and compositions thereof
 Mexico | Pending
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            methods for generating engineered memory-like nk cells and compositions thereof
 Brazil | Pending
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            methods for generating engineered memory-like nk cells and compositions thereof
 Singapore | Pending
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