Nanobody Based Imaging and Targeting of ECM in Disease and Development

Exclusively Licensed

Methods for developing disease-related nanobodies and related products and kits are provided. The disease- specific proteins are extracellular matrix (ECM) proteins, domains or epitopes that are associated with various aspects of disease and are not present, or are present in very low quantities, in non-diseased individuals. Highly effective nanobodies capable of specifically binding to these ECM protein epitopes useful in in vivo imaging assays, the detection, diagnosis and treatment of diseases as well as monitoring therapeutic progress in a patient with a disease are provided herein.

Researchers

Richard Hynes / Yushu Xie / Noor Jailkhani / Hidde Ploegh

Departments: Department of Biology
Technology Areas: Biotechnology: Sensors & Monitoring / Sensing & Imaging: Imaging / Therapeutics: Proteins & Antibodies
Impact Areas: Healthy Living

  • nanobody based imaging and targeting of ecm in disease and development
    Japan | Granted | 7,644,441
  • nanobody based imaging and targeting of ecm in disease and development
    United States of America | Granted | 11,597,769
  • nanobody based imaging and targeting of ecm in disease and development
    United States of America | Published application
  • nanobody based imaging and targeting of ecm in disease and development
    Japan | Published application
  • nanobody based imaging and targeting of ecm in disease and development
    China | Published application
  • nanobody based imaging and targeting of ecm in disease and development
    European Patent Convention | Published application

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