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Probing and Manipulating Cell Functions Through Intracellular Delivery

Exclusively Licensed Technology / Case number: #17162HJ
Robert Langer / Sophia Liu / Megan Heimann / George Hartoularos / Shirley Mao / Gregory Szeto / Armon Sharei / Ulrich Von Andrian / Pamela Basto / Siddharth Jhunjhunwala / Darrell J Irvine / Klavs F. Jensen
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Antibody Brush Prodrug Conjugates

Exclusively Licensed Technology / Case number: #23260
Jeremiah A. Johnson / Samantha Kristufek / Yutong Dai / Landon Kilgallon / Valerie Lensch / Bin Liu / Wencong Wang / Peyton Shieh / Hung Nguyen
Technology Areas: Therapeutics
Impact Areas: Healthy Living

Gamma Entrainment Binds Higher Order Brain Regions, Improves Cognitive Function, and offers Neuroprotection

Exclusively Licensed Technology / Case number: #20070P
Li-Huei Tsai / Chinnakkaruppan Adaikkan
Technology Areas: Therapeutics
Impact Areas: Healthy Living

Methods and Compositions for Ameliorating or Inhibiting Decline in Memory or Intelligence or Improving Same

Exclusively Licensed Technology / Case number: #12090Q
Richard Wurtman / Lisa Teather / Judith Wurtman
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living

A Fully Synthetic Nanoparticle Vaccine Platform Technology Composed of Dendrimer-Based Lipidoid Nanomaterials, Self-Amplifying Ribose Nucleic Acids and Polyethylene Glycol

Exclusively Licensed Technology / Case number: #17873WJH
Robert Langer / David Canner / Jasdave Chahal / Omar Khan / Daniel Anderson / Hidde Ploegh / Tyler Jacks
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living

Rapid Solid Phase Peptide Synthesizer

Exclusively Licensed Technology / Case number: #15911
Klavs F. Jensen / Mark Simon / Bradley L. Pentelute / Patrick Heider / Andrea Adamo
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Delivery Device to Release Drug to Seminal Vesicle, the Prostate Gland, and the Ejaculatory Duct

Exclusively Licensed Technology / Case number: #12805J
Michael Cima / Irene Khalek / Heejin Lee / Jordan Dimitrakov
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living

Kinase Sensing via Hydroxyquinoline-Sensitized Europium Chelates

Exclusively Licensed Technology / Case number: #18646QJ
Barbara Imperiali / Juan Gonzalez Vera
Technology Areas: Diagnostics / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living

A New Platform for Combination Drug Delivery: Nanoparticles Built from a Platinum Crosslinker

Exclusively Licensed Technology / Case number: #16248
Jeremiah A. Johnson / Longyan Liao
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials

Enabling the Injectability of Concentrated Drug Formulations and Solid Particles via Droplet Lubrication

Exclusively Licensed Technology / Case number: #20744
Kripa K Varanasi / Maxime Costalonga / Vishnu Jayaprakash
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living

Neuroprotective Effects of Combined Sensory Stimulation

Exclusively Licensed Technology / Case number: #19699
Li-Huei Tsai / Anthony Martorell / Ho-Jun Suk / Edward Stuart Boyden
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living

"Click-Type" Modifications of Peptides via SNAr Reaction of Thiols with Fluorinated Aromatic Molecules

Exclusively Licensed Technology / Case number: #15765
Stephen Buchwald / Chi Zhang / Yekui Zou / Alexander Spokoyny / Bradley L. Pentelute
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living

End-Modified Poly(b-amino ester)s

Non-Exclusively Licensed Technology / Case number: #12049Q
Robert Langer / Gregory Zugates / Andreas Zumbuehl / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
License

Uses of Chemicals to Modulate GSK-3B/B-Catenin Signaling for Treatment of Bipolar Disorder and Other Brain Disorders

Technology / Case number: #13480BJ
Stephen Haggarty / Michael Lewis / Edward Holson / Qian Pan / Joshua Ketterman / Tracey Petryshen / Daniel Fass
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
License

Novel Full Spectrum Anti-Dengue Antibody

Exclusively Licensed Technology / Case number: #16643
Ram Sasisekharan / Kannan Tharakaraman
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Peptide and Protein Modification to Afford Sox-Based Kinase Sensors

Exclusively Licensed Technology / Case number: #12133Q
Barbara Imperiali / Dora Carrico-Moniz / Elvedin Lukovic
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Molecular Determinants of Human Adaptation of H5N1 Influenza A Virus Hemagglutinin

Exclusively Licensed Technology / Case number: #14274
Rahul Raman / Kannan Tharakaraman / Karthik Viswanathan / Ram Sasisekharan
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Combination Therapies for Prostate and Breast Cancer with Abiraterone

Exclusively Licensed Technology / Case number: #16690Q
Michael Yaffe / Jesse C Patterson
Technology Areas: Therapeutics
Impact Areas: Healthy Living

Bortezomib Prodrugs

Exclusively Licensed Technology / Case number: #20771JQ
Jeremiah A. Johnson / Irene Ghobrial / Alexandre Detappe / Hung Nguyen / Yivan Jiang / Paiman Ghoroghchian
Technology Areas: Therapeutics
Impact Areas: Healthy Living

Molecular Design of Antibodies with Enhanced Stability

Non-Exclusively Licensed Technology / Case number: #13229J
Bernhardt Trout / Veysel Kayser / Vladimir Voynov / Bernhard Helk / Naresh Chennamsetty
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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