"Click-Type" Modifications of Peptides via SNAr Reaction of Thiols with Fluorinated Aromatic Molecules
Exclusively Licensed
Invention type: Technology
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Case number: #15765
Disclosed are compounds and methods relating to a chemical transformation for the conjugation of unprotected peptide biomolecules via a SNAr process between highly fluorinated aryl moieties and thiols (“fluoroaryl-thiol-click”).
Researchers
Stephen Buchwald
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Chi Zhang
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Yekui Zou
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Alexander Spokoyny
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Bradley L. Pentelute
Departments: Department of Chemistry
Technology Areas: Biotechnology: Synthetic Biology / Chemicals & Materials: Catalysis & Synthesis / Therapeutics: Nucleic Acids, Proteins & Antibodies
Impact Areas: Healthy Living
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modification of peptides via snar reactions of thiols with fluorinated aromatics
United States of America | Granted | 9,018,172
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