"Click-Type" Modifications of Peptides via SNAr Reaction of Thiols with Fluorinated Aromatic Molecules

Exclusively Licensed

Disclosed are compounds and methods relating to a chemical transformation for the conjugation of unprotected peptide biomolecules via a SNAr process between highly fluorinated aryl moieties and thiols (“fluoroaryl-thiol-click”).

Researchers

Stephen Buchwald / Chi Zhang / Yekui Zou / Alexander Spokoyny / Bradley L. Pentelute

Departments: Department of Chemistry
Technology Areas: Biotechnology: Synthetic Biology / Chemicals & Materials: Catalysis & Synthesis / Therapeutics: Nucleic Acids, Proteins & Antibodies
Impact Areas: Healthy Living

  • modification of peptides via snar reactions of thiols with fluorinated aromatics
    United States of America | Granted | 9,018,172

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