Molecular Design of Antibodies with Enhanced Stability
The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.
Researchers
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methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
United States of America | Granted | 9,922,164 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
Canada | Granted | 2,727,936 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
China | Granted | 200,980,128,287 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
European Patent Convention | Granted | 2,310,970 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
Japan | Granted | 5,694,150 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
Korea (south) | Granted | 1,854,724 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
Austria | Granted | 2,310,970 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
Germany | Granted | 2,310,970 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
France | Granted | 2,310,970 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
United Kingdom | Granted | 2,310,970 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
Italy | Granted | 2,310,970 -
methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
Spain | Granted | 2,310,970
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