Probing and Manipulating Cell Functions Through Intracellular Delivery

Exclusively Licensed

A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.

Researchers

Robert Langer / Sophia Liu / Megan Heimann / George Hartoularos / Shirley Mao / Gregory Szeto / Armon Sharei / Ulrich Von Andrian / Pamela Basto / Siddharth Jhunjhunwala / Darrell J Irvine / Klavs F. Jensen

Departments: Office of the Institute Professors, Department of Chemical Engineering
Technology Areas: Biotechnology: Biomedical Devices & Systems / Drug Discovery and Research Tools: Cell Interrogation / Therapeutics: Nucleic Acids, Proteins & Antibodies, Small Molecules
Impact Areas: Healthy Living

  • delivery of biomolecules to immune cells
    United States of America | Published application
  • delivery of biomolecules to immune cells
    Singapore | Granted | 11,201,703,044
  • delivery of biomolecules to immune cells
    Japan | Granted | 7,523,203
  • delivery of biomolecules to immune cells
    European Patent Convention | Published application
  • delivery of biomolecules to immune cells
    Canada | Published application
  • delivery of biomolecules to immune cells
    United States of America | Granted | 11,111,472
  • delivery of biomolecules to immune cells
    Russian Federation | Granted | 2,739,794
  • delivery of biomolecules to immune cells
    Israel | Granted | 252,005
  • delivery of biomolecules to immune cells
    China | Published application
  • delivery of biomolecules to immune cells
    Korea (south) | Published application
  • delivery of biomolecules to immune cells
    Korea (south) | Published application
  • delivery of biomolecules to immune cells
    Japan | Published application
  • delivery of biomolecules to immune cells
    Australia | Granted | 2,022,201,222

Sign up for technology updates

Sign up now to receive the latest updates on cutting-edge technologies and innovations.