A Fully Synthetic Nanoparticle Vaccine Platform Technology Composed of Dendrimer-Based Lipidoid Nanomaterials, Self-Amplifying Ribose Nucleic Acids and Polyethylene Glycol
Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.
Researchers
-
compositions and methods for modified dendrimer nanoparticle delivery
United States of America | Published application -
compositions and methods for modified dendrimer nanoparticle vaccine delivery
Hong Kong | Published application -
compositions and methods for modified dendrimer nanoparticledelivery
United States of America | Granted | 10,548,959 -
compositions and methods for modified dendrimer nanoparticle vaccine delivery
European Patent Convention | Published application -
compositions and methods for modified dendrimer nanoparticle vaccine delivery
Australia | Granted | 2,016,326,695 -
compositions and methods for modified dendrimer nanoparticle vaccine delivery
Israel | Granted | 258,055 -
compositions and methods for modified dendrimer nanoparticle vaccine delivery
Japan | Granted | 6,991,977 -
compositions and methods for modified dendrimer nanoparticle vaccine delivery
Canada | Granted | 2,999,916 -
compositions and methods for modified dendrimer nanoparticle vaccine delivery
China | Published application
License this technology
Interested in this technology? Connect with our experienced licensing team to initiate the process.
Sign up for technology updates
Sign up now to receive the latest updates on cutting-edge technologies and innovations.