A Fully Synthetic Nanoparticle Vaccine Platform Technology Composed of Dendrimer-Based Lipidoid Nanomaterials, Self-Amplifying Ribose Nucleic Acids and Polyethylene Glycol

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Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.

Researchers

Robert Langer / David Canner / Jasdave Chahal / Omar Khan / Daniel Anderson / Hidde Ploegh / Tyler Jacks

Departments: Office of the Institute Professors, Department of Chemical Engineering, David H Koch Institute for Integrative Cancer Res
Technology Areas: Biotechnology: Biomanufacturing, Synthetic Biology / Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Nucleic Acids, Vaccines
Impact Areas: Healthy Living

  • compositions and methods for modified dendrimer nanoparticle delivery
    United States of America | Published application
  • compositions and methods for modified dendrimer nanoparticle vaccine delivery
    Hong Kong | Published application
  • compositions and methods for modified dendrimer nanoparticledelivery
    United States of America | Granted | 10,548,959
  • compositions and methods for modified dendrimer nanoparticle vaccine delivery
    European Patent Convention | Published application
  • compositions and methods for modified dendrimer nanoparticle vaccine delivery
    Australia | Granted | 2,016,326,695
  • compositions and methods for modified dendrimer nanoparticle vaccine delivery
    Israel | Granted | 258,055
  • compositions and methods for modified dendrimer nanoparticle vaccine delivery
    Japan | Granted | 6,991,977
  • compositions and methods for modified dendrimer nanoparticle vaccine delivery
    Canada | Granted | 2,999,916
  • compositions and methods for modified dendrimer nanoparticle vaccine delivery
    China | Published application

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