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Cyclin-Dependent Kinase 5 (Cdk5) Inhibitory Peptide

Technology / Case number: #19569P
Li-Huei Tsai / Jinsoo Seo
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Glycan-Binding Properties of the 2009 'Swine Flu' H1N1 Influenza A Virus Hemagglutinin and its Mutant Forms

Exclusively Licensed Technology / Case number: #13812
Rahul Raman / Akila Jayaraman / Karthik Viswanathan / Zachary Shriver / Ram Sasisekharan
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Thermostabilization of Dry Lipid Nanoparticle Encapsulating mRNA using Polyvinylpyrrolidone and/or Polyvinyl Alcohol

Exclusively Licensed Technology / Case number: #22963
Robert Langer / John Daristotle / Maria Kanelli / Aurelien Vander Straeten / Morteza Sarmadi / Joseph Collins / Ana Jaklenec
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living

QTY Replacement to Design Water-Soluble Membrane Proteins and Uses Thereof

Exclusively Licensed Technology / Case number: #14760
Alexander Rich / Lotta Tollstoy Tegler / Karolina Corin / Shuguang Zhang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living

Large Hydrogel Capsules (>1mm) for Encapsulation of Therapeutic Cells and Cell Aggregates

Exclusively Licensed Technology / Case number: #16104JQ
Robert Langer / Alan Chiu / Omid Veiseh / Joshua Doloff / Delai Chen / Arturo Vegas / Christian Kastrup / Minglin Ma / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials

Strain-Programmable Dressing for Diabetic Wound Healing

Exclusively Licensed Technology / Case number: #22710J
Xuanhe Zhao / Georgios Theocharidis / Aristidis Veves / Heejung Roh / Hyunwoo Yuk
Technology Areas: Biomaterials & Bioelectronics / Therapeutics
Impact Areas: Healthy Living

L-SOMA: Oral Delivery of a Biologic Molecule to the Stomach Wall via a Liquid Injection

Technology / Case number: #21194QJ
Robert Langer / Andreas Vegge / Jorrit Jeroen Water / Xiaoya Lu / Mikkel Wennemoes Hvitfeld Ley / Brian Jensen / Mette Poulsen / Jesper Windum / Brian Mouridsen / Mikkel Oliver Jespersen / Morten Frederiksen / Alex Abramson / Giovanni Traverso
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Devices for Needless Drug Delivery in the GI tract

Technology / Case number: #21911QJ
Robert Langer / Adam Jun Bohr / Aghiad Ghazal / Drago Sticker / Cody Cleveland / Torben Sebastia Last / Yi Lu / Graham Arrick / Declan Gwynne / Sean You / Jacob Wainer / Niclas Roxhed / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Engineered Binding Proteins that Specifically Target Bacteria

Exclusively Licensed Technology / Case number: #22368
Hadley Sikes / Yining Hao / Ki-Joo Sung
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living

Fanzors are RNA-Guided Nucleases Encoded in Eukaryotic Genomes

Technology / Case number: #24942
Omar Abudayyeh / Kaiyi Jiang / Justin Lim / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Compacted Powder Needles for Intramucosal Delivery

Technology / Case number: #21149QJ
Giovanni Traverso / Morten Frederiksen
Technology Areas: Biomaterials & Bioelectronics / Therapeutics
Impact Areas: Healthy Living
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Prolonged-Release Hydrogel Formulations of Toll-Like Receptor Agonists for Intratumoral Injection to Increase Immunotherapy Response

Technology / Case number: #23215J
Robert Langer / Umar Mahmood / Eric Wehrenberg-Klee / Gabrielle Ndakwah / Jan-Georg Rosenboom / Avik Som / Arijit Basu / Giovanni Traverso
Technology Areas: Therapeutics
Impact Areas: Healthy Living
License

Branched Poly(-amino esters) for the Delivery of Nucleic Acids

Technology / Case number: #20333JQ
Robert Langer / Gary Liu / James Byrne / Netra Kamat / Hyunjoon Kim / Daniel Reker / Grace Junyue Zhong / Ameya Kirtane / Yunhua Shi / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Amino Acid, Peptide, Polypeptide-Lipids (APPL) Derivatives and Uses Thereof

Technology / Case number: #14910Q
Robert Langer / Akinleye Alabi / Yunlong Zhang / Yizhou Dong / Yi Chen / Delai Chen / Arturo Vegas / Kevin Love / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Method for Quantitative Monitoring of In Vivo Tumor Oxygenation

Technology / Case number: #19207JQ
Michael Cima / Ehud Schmidt / Robert Cormack / Larissa Lee / Gregory Ekchian
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Amplitude Spectroscopy of a Solid-State Artificial Atom

Technology / Case number: #13407L
Karl Berggren / Terry Orlando / Leonid Levitov / William Oliver / Sergio Valenzuela / Mark Rudner / David Berns
Technology Areas: Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
License

Discovery and Engineering of Novel Integrases for High-Efficiency Gene Integration

Technology / Case number: #23554
Omar Abudayyeh / Justin Lim / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

Biodegradable Lipid-Like Materials for Applications in siRNA Delivery

Technology / Case number: #15420
Robert Langer / Joseph Dorkin / Yunlong Zhang / Arturo Vegas / Kathryn Whitehead / Daniel Anderson
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

2-Aminoindole-Class Antimalarials

Technology / Case number: #14097BJ
Jon Clardy / Elyse Bourque / Yibin Xiang / Renato Skerlj / Edmund Sybertz / Joseph Cortese / Mary Lynn Baniecki / Roger Wiegand / Dyann Wirth / Cassandra Celatka / Sameer Urgaonkar / Ralph Mazitschek
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Programmable Insertion Approaches Via Reverse Transcriptase Recruitment

Technology / Case number: #23685
Omar Abudayyeh / Kaiyi Jiang / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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