QTY Replacement to Design Water-Soluble Membrane Proteins and Uses Thereof
Exclusively Licensed
Invention type: Technology
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Case number: #14760
The present invention is directed to a method of preparing a water-soluble variant of a G-protein coupled receptor (GPCR), the method comprising replacing residues leucine (L), isoleucine (I), valine (V), and phenylalanine (F) in hydrophilic surface α-helical positions b, c, and f but not positions a, d, e, and g within the 7-transmembrane α-helical domain of the GPCR with glutamine (Q), threonine (T), threonine (T), and tyrosine (Y), respectively.
Researchers
Alexander Rich
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Lotta Tollstoy Tegler
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Karolina Corin
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Shuguang Zhang
Departments: Media Lab
Technology Areas: Biotechnology: Synthetic Biology / Therapeutics: Proteins & Antibodies
Impact Areas: Healthy Living
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water soluble membrane proteins and methods for the preparation and use thereof
United States of America | Granted | 10,035,837 -
water soluble membrane proteins and methods for the preparation and use thereof
United States of America | Granted | 8,637,452 -
water soluble membrane proteins and methods for the preparation and use thereof
Japan | Granted | 6,263,773 -
water soluble membrane proteins and methods for the preparation and use thereof
India | Pending -
water soluble membrane proteins and methods for the preparation and use thereof
Israel | Granted | 227,886 -
water soluble membrane proteins and methods for the preparation and use thereof
Mexico | Granted | 347,038 -
water soluble membrane proteins and methods for the preparation and use thereof
Korea (south) | Granted | 10 -
water soluble membrane proteins and methods for the preparation and use thereof
European Patent Convention | Granted | 2,709,647 -
water soluble membrane proteins and methods for the preparation and use thereof
United States of America | Granted | 9,309,302 -
qty replacement to design water-soluble membrane proteins and uses thereof
Hong Kong | Granted | 1,194,294 -
water soluble membrane proteins and methods for the preparation and use thereof
Singapore | Granted | 0 -
water soluble membrane proteins and methods for the preparation and use thereof
Germany | Granted | 2,709,647 -
water soluble membrane proteins and methods for the preparation and use thereof
United Kingdom | Granted | 2,709,647
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