Amino Acid, Peptide, Polypeptide-Lipids (APPL) Derivatives and Uses Thereof
Invention type: Technology
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Case number: #14910Q
Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein:
Researchers
Kevin Love
/
Arturo Vegas
/
Delai Chen
/
Yi Chen
/
Yizhou Dong
/
Yunlong Zhang
/
Akinleye Alabi
/
Robert Langer
/
Daniel Anderson
Departments: Office of the Institute Professors, Department of Chemical Engineering
Technology Areas: Biotechnology: DNA & RNA Editing / Therapeutics: Nucleic Acids, Proteins & Antibodies
Impact Areas: Healthy Living
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amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof
United States of America | Granted | 9,512,073 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Brazil | Pending -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Canada | Granted | 2,853,522 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Chile | Granted | 61 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
China | Granted | 104,136,419 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
European Patent Convention | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
India | Granted | 347,600 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Israel | Granted | 232,158 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Japan | Granted | 6,151,707 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Korea (south) | Published application -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Mexico | Granted | 363,734 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
New Zealand | Granted | 624,223 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Peru | Granted | 9,135 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Eurasian Patent Organization | Granted | 32,088 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
South Africa | Pending -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Ukraine | Granted | 119,028 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Singapore | Granted | 11,201,401,885 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Australia | Granted | 2,012,328,570 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Hong Kong | Granted | 1,201,525 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
New Zealand | Granted | 719,941 -
amino acid-, peptide- and polypeptide-lipids, isomers, compositions, uses thereof
United States of America | Granted | 10,086,013 -
piperazine-2,5-dione derivatives, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments
Israel | Granted | 250,740 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
Japan | Granted | 6,522,690 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
New Zealand | Granted | 733,610 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
China | Granted | 0 -
amino acid, peptide, polypeptide-lipids (appl) derivatives and uses thereof
Australia | Granted | 2,017,265,103 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
South Africa | Granted | 2,018 -
piperazine-2,5-dione derivatives, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments
Israel | Granted | 259,414 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Mexico | Granted | 410,622 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
Eurasian Patent Organization | Granted | 40,020 -
amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof
United States of America | Granted | 10,682,374 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Peru | Granted | 11,933 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
New Zealand | Granted | 747,501 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
India | Granted | 474,675 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
Japan | Granted | 6,973,805 -
piperazine-2,5-dione derivatives, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments
Israel | Granted | 268,756 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
Korea (south) | Granted | 10 -
amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof
United States of America | Granted | 11,458,158 -
amino acid derivatives functionalized on the n-terminus capable of forming drug encapsulating microspheres and uses thereof
Australia | Granted | 2,020,201,387 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
India | Granted | 521,029 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
China | Published application -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
Korea (south) | Granted | 10 -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
Japan | Granted | 7,527,650 -
amino acid derivatives functionalized on the n-terminus capable of forming drug encapsulating microspheres and uses thereof
Australia | Granted | 2,021,257,964 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
United Kingdom | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
France | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Germany | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Netherlands | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Switzerland | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Liechtenstein | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Ireland | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Italy | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Turkey | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Spain | Granted | 2,771,319 -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
European Patent Convention | Published application -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Brazil | Pending -
amino acid derivatives functionalized on the n-terminal capable of forming drug incapsulating microspheres
Brazil | Pending -
amino acid-, peptide- and polypeptide-lipids, isomers,compositions, and uses thereof
Belgium | Granted | 2,771,319 -
amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof
United States of America | Published application -
amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
Korea (south) | Granted | 10 -
amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof
Hong Kong | Pending
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