Glycan-Binding Properties of the 2009 'Swine Flu' H1N1 Influenza A Virus Hemagglutinin and its Mutant Forms

Exclusively Licensed

The present invention provides HA polypeptides (e.g., H1 HA polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding agents that bind to HA polypeptides (e.g., H1 HA polypeptides), and reagents and methods relating thereto. The present invention provides interfering agents that inhibit the binding of HA polypeptides (e.g., H1 HA polypeptides) to HA receptors, and reagents and methods relating thereto. The present invention provides compositions and methods for treating, preventing, and/or diagnosing influenza infection utilizing HA polypeptides, HA polypeptide binding agents, HA polypeptide interfering agents, and/or vaccine compositions comprising any of the foregoing.

Researchers

Rahul Raman / Akila Jayaraman / Karthik Viswanathan / Zachary Shriver / Ram Sasisekharan

Departments: Department of Biological Engineering, School of Engineering
Technology Areas: Diagnostics: Assays / Drug Discovery and Research Tools: Genomics & Proteomics / Therapeutics: Proteins & Antibodies, Vaccines
Impact Areas: Healthy Living

  • glycan-binding properties of the 2009 'swine flu' h1n1 influenza a virus hemagglutinin and its mutant forms
    Italy | Granted | 502,016,000,034,063
  • compositions and methods for diagnosing and/or treating influenza infection
    United States of America | Granted | 9,278,998
  • glycan-binding properties of the 2009 'swine flu' h1n1 influenza a virus hemagglutinin and its mutant forms
    Australia | Granted | 201,026,619
  • glycan-binding properties of the 2009 'swine flu' h1n1 influenza a virus hemagglutinin and its mutant forms
    Canada | Granted | 2,766,899
  • glycan-binding properties of the 2009 'swine flu' h1n1 influenza a virus hemagglutinin and its mutant forms
    European Patent Convention | Granted | 2,448,596
  • compositions and methods for diagnosing and/or treating influenza infection
    Japan | Granted | 5,886,194
  • compositions and methods for diagnosing and/or treating influenza infection
    United States of America | Granted | 9,709,567
  • glycan-binding properties of the 2009 'swine flu' h1n1 influenza a virus hemagglutinin and its mutant forms
    Germany | Granted | 2,448,596
  • glycan-binding properties of the 2009 'swine flu' h1n1 influenza a virus hemagglutinin and its mutant forms
    Spain | Granted | 2,448,596
  • glycan-binding properties of the 2009 'swine flu' h1n1 influenza a virus hemagglutinin and its mutant forms
    France | Granted | 2,448,596
  • glycan-binding properties of the 2009 'swine flu' h1n1 influenza a virus hemagglutinin and its mutant forms
    United Kingdom | Granted | 2,448,596

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