Biodegradable Lipid-Like Materials for Applications in siRNA Delivery

Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.

Researchers

Kathryn Whitehead / Arturo Vegas / Yunlong Zhang / Joseph Dorkin / Robert Langer / Daniel Anderson

Departments: Office of the Institute Professors, Department of Chemical Engineering
Technology Areas: Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Nucleic Acids
Impact Areas: Healthy Living

  • amine-containing lipidoids and uses thereof
    United States of America | Granted | 9,227,917
  • amine-containing lipidoids and uses thereof
    United States of America | Granted | 9,439,968

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