L-SOMA: Oral Delivery of a Biologic Molecule to the Stomach Wall via a Liquid Injection

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

Researchers

Giovanni Traverso / Alex Abramson / Robert Langer / Morten Frederiksen / Mikkel Oliver Jespersen / Brian Mouridsen / Jesper Windum / Mette Poulsen / Brian Jensen / Mikkel Wennemoes Hvitfeld Ley / Xiaoya Lu / Jorrit Jeroen Water / Andreas Vegge

Departments: Department of Mechanical Engineering, Office of the Institute Professors
Technology Areas: Biotechnology: Biomanufacturing / Therapeutics: Proteins & Antibodies, Small Molecules
Impact Areas: Healthy Living

  • systems and methods for liquid injection
    United States of America | Granted | 11,771,829
  • systems and methods for liquid injection
    European Patent Convention | Published application
  • systems and methods for liquid injection
    Japan | Published application
  • systems and methods for liquid injection
    China | Granted | 202,080,025,857

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