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Machine Learning-Guided Discovery of Nanoparticle Formulations Maximizing mRNA Transfection

Technology / Case number: #25890J
Giovanni Traverso / Ameya Kirtane / Joshua Bernstock / Alvin Chan / Jonathan Woo / Deepak Subramanian / Simon Qu / Xisha Huang / Hao Song / Taksim Ahmed
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Computational Method for Identifying the Biophysical Interactions that Determine Human T Cell Specificity from Structural Data and Primary Amino Acid Sequences

Technology / Case number: #26026J
Xingcheng Lin / Herbert Levine / José Onuchic / Ailun Wang / Jason George
Technology Areas: Computer Science / Therapeutics
Impact Areas: Healthy Living
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A Novel Injectable Thiol-Acrylate Poly(ethylene Glycol) Hydrogel for Sustained Release of Methylprednisolone Sodium Succinate

Technology / Case number: #14439J
Eric Woodard / Christopher Pritchard / Daniel Siegwart / Timothy O'Shea / Francis Reynolds / Jonathan Slotkin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Self Assembled RSV Nanoparticle Vaccines

Technology / Case number: #16549
Vidya Subramanian / Aditya Raguram / Ram Sasisekharan
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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SNAPPLE - Sequencing-Mediated Numerical Analysis of Parallel Proximity Ligation Events

Technology / Case number: #13615B
Andreas Gnirke / Erez Lieberman / Daniel Aird
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Translocation of Non-Natural Chemical Entities Through Anthrax Protective Antigen Pore

Technology / Case number: #15639J
Bradley L. Pentelute / Xiaoli Liao / Amy Rabideau / Jingjing Ling / Gizem Akcay / R. Collier
Technology Areas: Computer Science / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Efficient Purification of Ribulose-1,5-bisphosphate Carboxylase/Oxygenase (RuBisCO) from Complex Cellular material and leaf Lysates using Liquid-Liquid Phase Separation

Technology / Case number: #26071
Matthew D. Shoulders / Robbie Wilson / Yunlong Zhao
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Connected World
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Methods for the Production of Porous Scaffolds Comprising Multiple Layers with Distinct Characteristics

Technology / Case number: #11730QJ
Andrew Lynn / William Bonfield / Zachary Wissner-Gross / Lorna Gibson / Ioannis Yannas / Brendan Harley
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Intraoperative Coded Aperture Radioscintigraphic Imaging of Cancer

Technology, Software / Case number: #11901J
John Idoine / Richard Lanza / Roberto Accorsi / John Frangioni
Technology Areas: Biotechnology / Electronics & Photonics / Sensing & Imaging
Impact Areas: Healthy Living
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sMutants of Channelrhodopsins with Altered Ion Selectivity

Technology / Case number: #16934TE
Edward Stuart Boyden / Nathan Klapoetke / Amy Chuong / Yongku Cho / Fei Chen
Technology Areas: Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living
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A Novel Multiplexed Inertial Focusing Microfiltration System for Intra-Operative Blood Salvage Autotransfusion

Technology / Case number: #17212DJE
Chwee-Teck Lim / Guofeng Guan / Lidan Wu / Majid Ebrahimi Warkiani / Kah Ping Andy Tay / Jongyoon Han
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Colon Delivery Platform for Constipation Treatment

Technology / Case number: #20570JQ
Giovanni Traverso / Joshua Korzenik / Robert Langer / Christoph Winfried Johannes Steiger
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Modular Continuous Lyophilizer

Technology / Case number: #26102J
Richard D Braatz / Roberto Pisano / Steven Burcat / Alexander Slocum / Rohan Kadambi / Joshua Dittrich / Bernhardt Trout
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Connected World
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Ultrasound-Mediated Gastrointestinal Drug Delivery

Technology / Case number: #17807JQ
William Brugge / Avraham Schroeder / Giovanni Traverso / Baris Polat / Carl Schoellhammer / Robert Langer / Daniel Blankschtein
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Mucin-Inspired Glycopolypeptides for Managing Microbial Infections

Technology / Case number: #26189J
Katharina Ribbeck / Kelsey Wheeler / Michaela Gold / Jessica Kramer
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Women's Health
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CD80 is a Biomarker of p53 Activity and a Target for Cancer Therapy

Technology / Case number: #15386H
David Feldser / Leah Schmidt / Tyler Jacks
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Low-Cost, Robust, Optical Method of Measuring Object in Three-Dimensions at High Accuracy and High Resolution

Technology / Case number: #12920
Davide Marini / Carlos Hidrovo Chavez / Douglas Hart / Federico Frigerio
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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Biodegradable Polyamine-Fatty Acid Derived Lipidoids for Drug Delivery

Technology / Case number: #16367
Joseph Dorkin / Owen Fenton / Rebecca McClellan / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Patterned Light Beam and Patterned Light Block for Particle Position Measurement

Technology / Case number: #11699L
Jonathan Lin / George Haldeman / Antonio Sanchez-Rubio / Thomas Jeys / Vincenzo Daneau / Ronald Hoffeld / Nicholas Judson
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Climate Stabilization, Healthy Living
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Valency Controlled Quantum Dots with Tunable Number of Biotin Binding Sites

Technology / Case number: #12606B
Mark Howarth / Wenhao Liu / Moungi G Bawendi / Alice Ting
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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