A Hybrid, Vector-Free, Microfluidic Delivery Platform for Engineering Cell Function

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A microfluidic system for causing perturbations in a cell membrane includes (a) a microfluidic channel defining a lumen and configured such that a cell suspended in a buffer can pass there through, and (b) source or emitter of an energy field. The microfluidic channel may include a cell-deforming constriction. A diameter of the constriction may be a function of the diameter of the cell. Related apparatus, systems, techniques, and articles are also described.

Researchers

Robert Langer / Xiaoyun Ding / Armon Sharei / Klavs F. Jensen

Departments: Office of the Institute Professors, Department of Chemical Engineering
Technology Areas: Biotechnology: Biomedical Devices & Systems, Synthetic Biology / Drug Discovery and Research Tools: Cell Interrogation
Impact Areas: Healthy Living

  • disruption and field enabled delivery of compounds and compositions into cells
    Japan | Granted | 7,591,265
  • disruption and field enabled delivery of compounds and compositions into cells
    European Patent Convention | Published application
  • disruption and field enabled delivery of compounds and compositions into cells
    Canada | Granted | 2,964,138
  • disruption and field enabled delivery of compounds and compositions into cells
    China | Granted | 0
  • disruption and field enabled delivery of compounds and compositions into cells
    United States of America | Granted | 10,526,573
  • disruption and field enabled delivery of compounds and compositions into cells
    Japan | Granted | 6,846,345

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