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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Luke Rhym / Allen Jiang / Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Single-Cell RNA Sequencing Using Click-Chemistry

Technology / Case number: #20396
Dig Mahat / Phillip Sharp
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Quick Release Capsules for Small Intestine Delivery

Technology / Case number: #20105J
Carlo Giovanni Traverso / Daniel Minahan / Alex Abramson / Niclas Roxhed / Ester Caffarel Salvador / David Dellal / Vance Soares / Robert Langer / Christoph Winfried Johannes Steiger / Morten Frederiksen
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Engineering a Swine Macro-Organ Colorectal Cancer Platform to Combat Transport-Induced Chemotherapy Resistance

Technology / Case number: #22864JQ
Carlo Giovanni Traverso / Yunhua Shi / Vance Soares / Daniel Reker / Robert Langer
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Closed-Loop Ingestible Robot for Radiation and Chemical Sensing

Technology / Case number: #22735
Carlo Giovanni Traverso / Hen Wei Huang / James Byrne
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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Endovascular Injectable Stents for Cardiovascular Drug Delivery

Technology / Case number: #22578J
Carlo Giovanni Traverso / Sahab Babaee / Mazen Albaghdadi / Mohammed Chowdhury
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living, Advanced Materials
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Ingestible Electronic Pills for Hormone Modulation

Technology / Case number: #22427
Carlo Giovanni Traverso / Khalil Ramadi / James McRae
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Wireless Interlaminar Sensor (WINS): CNT Delamination Sensor with Environmental Compensation

Technology / Case number: #23855J
Brian Wardle / Luiz Henrique Acauan / Yosef (Yosi) Stein / Haozhe Wang / Haim Primo
Technology Areas: Chemicals & Materials / Communication Systems / Sensing & Imaging
Impact Areas: Advanced Materials
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Pupil Engineering Method to Enhance the Signal of the Real-time non-invasive Particle Size Distribution Probe in Powders and During Mixing, Drying, Blending, and Milling Processes

Technology / Case number: #24521
Allan Myerson / Richard Braatz / Qihang Zhang / Zhen Guo / Ajinkya Vikram Pandit / George Barbastathis
Technology Areas: Chemicals & Materials / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Advanced Materials
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High-Temperature Miniature Ultrasonic Probes

Technology / Case number: #24612
Hoagy O'Ghaffari / Matej Pec
Technology Areas: Sensing & Imaging
Impact Areas: Advanced Materials
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Device and Method for Imaging Shortwave Infrared Autofluorescence

Technology / Case number: #18527J
Oliver Bruns / Jessica Carr / Klaus Van Leyen / Yi Zheng / Marianne Aellen / Moungi Bawendi
Technology Areas: Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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In-Pipe Leak Detection System

Technology, Tangible Property / Case number: #19034JC
Rached Ben-Mansour / You Wu / Kristina Kim / Michael Henry / Kamal Youcef-Toumi
Technology Areas: Agriculture & Food / Environmental Engineering / Sensing & Imaging
Impact Areas: Sustainable Future
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Flexible Electronics for Analyte Detection

Technology / Case number: #21994J
Carlo Giovanni Traverso / Robert Langer / Hen Wei Huang / Siheng You / Luca Di Tizio
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Tissue Platform and Machine Learning Algorithm for Drug-Drug Transporter Interaction Discovery

Technology / Case number: #21883J
Carlo Giovanni Traverso / Yunhua Shi / Vance Soares / Daniel Reker / Robert Langer
Technology Areas: Biomaterials & Bioelectronics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Polymers for Messenger RNA Delivery to the Lung

Technology / Case number: #19314
Kevin Kauffman / James Kaczmarek / Asha Patel / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure-Guided Chemical Modification of Guide RNA and its Applications

Technology / Case number: #19175V
Hao Yin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Fully Implantable, Autonomous Closed-Loop System Capable of Long-Term Vital Signs Monitoring and Performing Lifesaving Treatment

Technology / Case number: #23387J
Carlo Giovanni Traverso / Hen Wei Huang / Seungho Lee / Saurav Maji / Peter Chai / Tom Kerssemakers / Ian Ballinger / Anantha Chandrakasan
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Computer Science / Energy & Distribution
Impact Areas: Healthy Living, Advanced Materials
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Tough Hydrogel Pills Inflating 100 Times in Volume Within 10 Min

Technology / Case number: #20059
Xuanhe Zhao / Shaoting Lin / Hyunwoo Yuk / German Parada Hernandez / Xinyue Liu
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Gastric Residence Electronics

Technology / Case number: #20092J
Carlo Giovanni Traverso / Yong Lin Kong / Robert Langer
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Communication Systems
Impact Areas: Healthy Living
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Electrically Driven Light-Emitting Tunnel Junctions

Technology / Case number: #18393
Farnaz Niroui / Thomas Mahony / Vladimir Bulovic / Jeffrey Lang
Technology Areas: Communication Systems / Sensing & Imaging
Impact Areas: Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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