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Invention Disclosure: Kinetic Sensing, Signal Generation, Feature Extraction, and Pattern Recognition for Control of Autonomous Wearable Leg Devices

Technology / Case number: #18945TE
Luke Mooney / Matthew Carney / Roman Stolyarov / Cameron Taylor / Hugh Herr
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Methods for Learning Network Architectures of Deep Convolutional Neural Networks under Resource Constraints

Technology / Case number: #20095L
Luke Skelly / Jason Thornton / Michael Chan / Ronald Duarte / Daniel Scarafoni
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Neural Efferent and Afferent Control of Spring Equilibrium, Damping, and Power in Backdrivable and Non-Backdrivable Series-Elastic Actuators Comprising Variable Series Stiffness Mechanisms

Technology / Case number: #20960TE
Matthew Carney / Roman Stolyarov / Emily Rogers-Bradley / Seong Ho Yeon / Hugh Herr
Technology Areas: Biotechnology / Computer Science / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Modular System for Lyophilization

Technology / Case number: #22603
Alexander Slocum / Bernhardt Trout
Technology Areas: Biotechnology / Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Sparse Closed-form Liquid Neural Algorithms for Out-of-Distribution Generalization on Edge Robots

Technology / Case number: #24660
Daniela Rus / Alexander Amini / Ramin Hasani / Mathias Lechner / Makram Chahine
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Industrial Engineering & Automation
Impact Areas: Healthy Living, Advanced Materials
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Mobile Physical Telemedicine

Technology / Case number: #24924
Johannes Lachner / Federico Tessari / Neville Hogan
Technology Areas: Biotechnology / Communication Systems / Computer Science / Industrial Engineering & Automation
Impact Areas: Healthy Living, Uncharted Frontiers, Connected World
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Genotype-Directed Local Delivery of Targeted Therapeutics at the Tumor Margin

Technology / Case number: #19863J
Carlo Giovanni Traverso / Ameya Kirtane / Daniel Cahill / Ganesh Shankar / Robert Langer
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Formulated, Biodegradable Polymeric Nanoparticles for Nucleic Acid Delivery to Non-Liver Targets

Technology / Case number: #19802
Kevin Kauffman / James Kaczmarek / Asha Patel / Luke Rhym / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Luke Rhym / Allen Jiang / Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Bioinspired Design of Self-Adjuvanted C3d-Fusion SARS-CoV-2 mRNA Vaccines

Technology / Case number: #23326
Robert Langer / Bowen Li / Allen Jiang / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Closed-Loop Ingestible Robot for Radiation and Chemical Sensing

Technology / Case number: #22735
Carlo Giovanni Traverso / Hen Wei Huang / James Byrne
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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Derivation of Enteroendocrine Cells and Insulin Expressing Cells

Technology / Case number: #18445J
Jeffrey Karp / Xiaolei Yin / Robert Langer
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Motorized and Balloon Dynamic Satiety Stimulator

Technology / Case number: #25050J
Carlo Giovanni Traverso / Neil Jia
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Healthy Living
License

A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Brice Curtin / Jasmin Kruell / Catherine Henry / Sebastian Pomplun / Christina Woo / Chia-fu Chang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Small Molecule Inhibitors of Interleukin-4

Technology / Case number: #22186
Angela Koehler / Arturo Vegas / Shelby Doyle / Becky Leifer / Sean Quinnell / Stephen Nestor / Kelly Tan / Luke Ceo / Daniel Sheehy
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Pooled Screening Identifies Genomic Features (Biomarkers) Modulating Nanoparticle-Cell Interactions

Technology / Case number: #22785J
Angela Koehler / Natalie Boehnke / Joelle Straehla / Paula Hammond
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Magnetically Steerable, Soft-Bodied Continuum Robots

Technology / Case number: #21435
Xuanhe Zhao / Yoonho Kim
Technology Areas: Biotechnology / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
License

Soft Robotic, 3D-Printed Simulator of Heart Function and Disease

Technology / Case number: #25013J
Ellen Roche / Caglar Ozturk / Luca Rosalia / Jean Bonnemain / Sophie Wang / Christopher Nguyen / Debkalpa Goswami
Technology Areas: Biotechnology / Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Healthy Living
License

Spatially Localized Gene Delivery of Adeno-Associated Viruses

Technology / Case number: #25055
Polina Anikeeva / Keisuke Nagao
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Combinations of Anesthetics as Therapies for Treatment-Resistant Depression

Technology / Case number: #25342P
Emery Brown / Sirma Orguc / Ohyoon Kwon / Bryan Tseng / Macauley Breault / Gloria Kang
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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