Resonance-Based Monitoring System of Biological Deposition


This device wirelessly measures the extent and properties of biological deposition on the surface of implanted medical devices. It may be used to monitor patients for complications such as thrombus, pannus, and/or pathogenic biofilm at the blood-machine interfaces. It is also capable of identifying endothelialization on successfully implanted medical devices. These detections would allow physicians to better treat patients with implants such as prosthetic heart valve leaflets, catheters, and other vascular implants.

Problem Addressed

The formation of harmful biological deposition such as thrombus, pannus, and biofilm can lead to a heart attack or stroke, increase the risk of sepsis, or necessitate the replacement of implants. Identifying the formation of endothelial cells on implants is important for clinicians, because it may prevent thrombus formation. Current biological deposition detection procedures include cinefluoroscopy, transthoracic and transoesophageal echocardiography, and angiography. These methodologies only detect either functional impairment of mechanical implants or large depositions that obstruct blood flow. They fail to identify the extent and properties of deposition on implanted medical devices. There is a need for a device, such as this, that can identify and monitor the deposition of beneficial and harmful biological materials on implantable medical devices.


This biological deposition detection device utilizes an electrical resonator: a sensor that is positioned on the surface of a medical device prior to implantation. The sensor has resonant frequencies that are altered by the extent and properties of deposition on the medical device surface. This device also utilizes an external hand-held measurement system: a reader capable of wirelessly determining the sensor’s resonant frequencies. The electrical permittivity of depositions such as thrombus, pannus, endothelial cells, pathogenic biofilms, and human blood are distinct due to differences in molecular composition and spatial geometry of the cells. As biological deposition builds, the sensor’s resonant frequencies change. After processing the change in resonant frequencies, the reader delivers a deposition report to the user. In conjunction with other clinical data, healthcare providers may use this information to help inform patient treatment.


  • Identifies properties of biological deposition to classify the material
  • Measures extent of deposition on the medical device surface quickly and directly
  • Wireless communication between sensor and reader