Hydrodynamically Controlled Electric Fields for High Throughput Transformation & High Throughput Parallel Transformation Platform

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Methods and apparatuses for cell electroporation are provided. An apparatus includes a fluid transport structure, such as a pipette, that includes an electroporation structure defining a flow path having a constriction. The fluid transport structure also includes at least two conductive elements configured to produce an electric field in the flow path. The conductive elements are in operative arrangement with each other and are configured to expose cells contained within a cell suspension flowing through the fluid transport structure to an electric field that is sufficient to electroporate at least a subset of the cells in the flow path.

Researchers

Cullen R. Buie / Rameech McCormack / Paulo Garcia Dominguez / Zhifei Ge

Departments: Department of Mechanical Engineering
Technology Areas: Biotechnology: Biomanufacturing, Synthetic Biology / Drug Discovery and Research Tools: Cell Interrogation / Industrial Engineering & Automation: Manufacturing & Equipment

  • hydrodynamically controlled electric fields for high throughput transformation & high throughput parallel transformation platform
    Hong Kong | Pending
  • hydrodynamically controlled electric fields for high throughput transformation & high throughput paralleltransformation platform
    European Patent Convention | Published application
  • hydrodynamically controlled electric fields for high throughput transformation & high throughput parallel transformation platform
    United States of America | Published application

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