An application would be an antibody against mouse HRI N-terminus.
The heme-regulated inhibitor (HRI) is essential for production of hemoglobin and red blood cells. This technology is a polyclonal antibody against the N-terminus of HRI, a highly conserved domain that is essential for downregulation of HRI activity by heme. This antibody enables imaging and measurements of HRI in multiple species and is a useful tool for studying stress-induced translational regulation and hematology.
- Enables study of the HRI protein, which is essential for hemoglobin and red blood cell production, making it a useful tool for hematology research
- Binds the highly conserved N-terminus, so it can be used across many species including human, rabbit, and mouse