This technology is a DNA analysis software for identifying the lab-of-origin of DNA sequences with applications in biosecurity, biointelligence, and IP protection.
Improvements in genetic engineering techniques has made the design and synthesis of DNA sequences easier than ever. DNA engineering has sparked immense innovation in biotechnology; however, it is also now easier to apply these techniques for nefarious purposes such as engineering biological weapons or stealing pieces of proprietary DNA. Identifying the lab-of-origin of a DNA sequence could provide important evidence in cases such as these, but current DNA analysis tools are ill equipped to handle synthetic DNA sequences. Therefore, there is a new need to develop software tools to facilitate analysis of engineered DNA sequences.
This technology uses an artificial intelligence neural network to identify the lab of origin of an engineered DNA sequence. The design choices made when building a new DNA tool are frequently dictated by lab history and culture, which leads to sequence similarities in DNA arising from any given laboratory. In addition to these rational design choices, unintentional marks such as silent mutations that don’t affect DNA functionality can create a unique signature for DNA constructs synthesized in a particular lab. This technology uses machine learning and artificial intelligence software to identify DNA sequence signatures that identify the lab-of-origin of the DNA. The inventors demonstrate that this AI technique is superior to BLAST, the most common DNA sequence comparison technique, at identifying lab-of-origin for engineered DNA, particularly for short sequences with commonly used motifs.
- Rapid, reliable analysis of engineered DNA sequences
- Identifies lab of origin with high confidence
- Superior to BLAST, particularly for identifying short sequences with commonly used DNA motifs