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Machine Learning-Guided Discovery of Nanoparticle Formulations Maximizing mRNA Transfection

Technology / Case number: #25890J
Giovanni Traverso / Taksim Ahmed / Hao Song / Xisha Huang / Simon Qu / Deepak Subramanian / Jonathan Woo / Alvin Chan / Joshua Bernstock / Ameya Kirtane
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Computational Method for Identifying the Biophysical Interactions that Determine Human T Cell Specificity from Structural Data and Primary Amino Acid Sequences

Technology / Case number: #26026J
Xingcheng Lin / Jason George / Ailun Wang / José Onuchic / Herbert Levine
Technology Areas: Computer Science / Therapeutics
Impact Areas: Healthy Living
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Efficient Purification of Ribulose-1,5-bisphosphate Carboxylase/Oxygenase (RuBisCO) from Complex Cellular material and leaf Lysates using Liquid-Liquid Phase Separation

Technology / Case number: #26071
Matthew D. Shoulders / Yunlong Zhao / Robbie Wilson
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Connected World
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Modular Continuous Lyophilizer

Technology / Case number: #26102J
Alexander Slocum / Joshua Dittrich / Rohan Kadambi / Steven Burcat / Roberto Pisano / Richard D Braatz / Bernhardt Trout
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Connected World
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Systems, Devices, and Methods Utilizing Hybrid Photonic Crystal Cavities

Technology / Case number: #26158J
Dirk R Englund / Andy Greenspon / Mark Dong / Ian Christen
Technology Areas: Electronics & Photonics / Sensing & Imaging
Impact Areas: Advanced Materials
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Reactive Extraction of Metals

Technology / Case number: #26160
Yet-Ming Chiang
Technology Areas: Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Connected World
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Mucin-Inspired Glycopolypeptides for Managing Microbial Infections

Technology / Case number: #26189J
Katharina Ribbeck / Jessica Kramer / Michaela Gold / Kelsey Wheeler
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Women's Health
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Cathode Layers for Photovoltaics Based on poly(3,4-ethylenedioxythiophene)

Technology / Case number: #15433J
Karen Gleason / Riccardo Po / Chiara Carbonera / Miles Barr / Vladimir Bulovic
Technology Areas: Chemicals & Materials / Energy & Distribution / Sensing & Imaging
Impact Areas: Advanced Materials
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A Gravity Loading Skinsuit

Technology / Case number: #13869
Dava Newman
Technology Areas: Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials
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High-Capacity DRX Cathode Materials for Lithium Ion Batteries

Technology / Case number: #15655
Gerbrand Ceder
Technology Areas: Chemicals & Materials / Energy & Distribution
Impact Areas: Sustainable Future, Advanced Materials
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Conservative Signal Processing Architectures for Asynchronous, Distributed Optimization:

Technology / Case number: #17185
Tom Baran / Tarek Lahlou
Technology Areas: Computer Science / Industrial Engineering & Automation
Impact Areas: Connected World
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Multi-Stage Membrane Distillation Process

Technology / Case number: #15901
John Lienhard / Edward Summers
Technology Areas: Environmental Engineering
Impact Areas: Climate Stabilization
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CD80 is a Biomarker of p53 Activity and a Target for Cancer Therapy

Technology / Case number: #15386H
Tyler Jacks / Leah Schmidt / David Feldser
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Poly(B-Amino Alcohols), Their Preparation and Uses Thereof

Technology / Case number: #14035QJ
Robert Langer / Wendy Liu / Minglin Ma / Daniel Anderson
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials
Impact Areas: Healthy Living
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Real-Time Traffic Aware Routing Using Historical Traffic Distributions

Technology / Case number: #13602
David K Gifford / Sejoon Lim / Daniela Rus / Samuel Madden / Hari Balakrishnan
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML)
Impact Areas: Connected World
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Fluorinated Coatings for Higher Performance Electrodes

Technology / Case number: #17249
Yogesh Surendranath / Sterling Chu / Stefan Kilyanek
Technology Areas: Chemicals & Materials / Energy & Distribution
Impact Areas: Advanced Materials
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Extension of a Finite Element Framework for Calculation of DNA Nanostructure Solution Shape, Mechanical, and Optical Properties

Technology / Case number: #16421
Klaus-Jurgen Bathe / Oskar Hallatschek / Etienne Boulais / Reza Sharifi Sedeh / Lun Yang / Keyao Pan / Matthew Adendorff / Do-Nyun Kim / Mark Bathe
Technology Areas: Computer Science
Impact Areas: Healthy Living
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A Low-Cost, Robust, Optical Method of Measuring Object in Three-Dimensions at High Accuracy and High Resolution

Technology / Case number: #12920
Douglas Hart / Carlos Hidrovo Chavez / Davide Marini / Federico Frigerio
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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High-Performance Systolic K-Way Merge Sorter Processor

Technology / Case number: #13396L
Bill Song
Technology Areas: Computer Science
Impact Areas: Connected World
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Biodegradable Polyamine-Fatty Acid Derived Lipidoids for Drug Delivery

Technology / Case number: #16367
Daniel Anderson / Rebecca McClellan / Owen Fenton / Joseph Dorkin
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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