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Using CRISPR/Cas9 to Encode Cellular History

Non-Exclusively Licensed Technology / Case number: #18025R
Alex Shalek / Alethe Gaillard de Saint Germain
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Genotype-Directed Local Delivery of Targeted Therapeutics at the Tumor Margin

Technology / Case number: #19863J
Robert Langer / Ganesh Shankar / Daniel Cahill / Ameya Kirtane / Giovanni Traverso
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Formulated, Biodegradable Polymeric Nanoparticles for Nucleic Acid Delivery to Non-Liver Targets

Technology / Case number: #19802
Daniel Anderson / Luke Rhym / Asha Patel / James Kaczmarek / Kevin Kauffman
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Screens for Exploring Biological Functions of Microscale Biological Systems

Technology / Case number: #19737JR
Paul Blainey / Navpreet Ranu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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New Ionizable Lipid Library Suitable for Multiple Organ Targeting Derived From High Throughput Combinatorial Synthesis and Screening

Technology / Case number: #23406
Daniel Anderson / Idris Raji / Akiva Gordon / Bowen Li
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Using over Wnt ing to Treat Colon Cancer: Small Molecule GSK3 Inhibitors and Novel Protein Isolation

Exclusively Licensed Technology / Case number: #23378JQ
George Eng / Jonathan Braverman / Omer Yilmaz
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living

Single-Cell RNA Sequencing Using Click-Chemistry

Technology / Case number: #20396
Phillip Sharp / Digbijay Mahat
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Diagnosis of Malignancy Using Developmental Relationships and Machine Learning

Technology / Case number: #23356
Salil Garg / Enrico Moiso
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Bioinspired Design of Self-Adjuvanted C3d-Fusion SARS-CoV-2 mRNA Vaccines

Technology / Case number: #23326
Robert Langer / Allen Jiang / Bowen Li / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Ingestible Chemical Energy Harvesting System with Extended Lifetime

Technology / Case number: #23174
Giovanni Traverso / So-Yoon Yang / Jason Li
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Energy & Distribution / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
License

Engineering a Swine Macro-Organ Colorectal Cancer Platform to Combat Transport-Induced Chemotherapy Resistance

Technology / Case number: #22864JQ
Robert Langer / Daniel Reker / Vance Soares / Yunhua Shi / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Highly Actively Co-Based Perovskites for Water Splitting

Technology / Case number: #14882
Yang Shao-Horn / Kevin May / Jin Suntivich
Technology Areas: Energy & Distribution / Environmental Engineering
Impact Areas: Sustainable Future
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Cellular Backpacks for Drug Delivery Across the Blood-Brain Barrier

Technology / Case number: #18547J
Robert Cohen / Natalya Klyachko / Yuling Zhao / Matthew Haney / Elena Batrakova / Roberta Polak / Michael F Rubner
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

In-Pipe Leak Detection System

Technology, Tangible Property / Case number: #19034JC
Kamal Youcef-Toumi / Michael Finn-Henry / Kris Kim / You Wu / Rached Ben-Mansour
Technology Areas: Agriculture & Food / Environmental Engineering / Sensing & Imaging
Impact Areas: Sustainable Future
License

Direct-Drive (Batteryless) Electrodialysis Separation using Flow-Commanded Current Control

Technology / Case number: #24538
Amos Winter / Jonathan Bessette / Shane Pratt
Technology Areas: Environmental Engineering
Impact Areas: Sustainable Future
License

Methods for Producing High-Level Squalene in Yarrowia Lipolytica

Exclusively Licensed Technology / Case number: #24579
Gregory Stephanopoulos / Yongshuo Ma
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living

Data Driven Material Discovery System

Technology / Case number: #21835J
Wojciech Matusik / Mina Konakovic Lukovic / Hanns-Hagen Goetzke / Bernhard Von Vacano / Klaus Stoll / Mina Lukovic / Wan Shou / Timothy Erps / Michael Foshey
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Industrial Engineering & Automation
Impact Areas: Advanced Materials
License

Machine Learning for the Design of Cancer Vaccine Adjuvants

Technology / Case number: #21680J
Robert Langer / Netra Kamat / Hyunjoon Kim / Lewis Scott Jones / Daniel Reker / Ameya Kirtane / Giovanni Traverso
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
License

Nucleotide Depletion as Differentiation Therapy in the Treatment of Cancer

Technology / Case number: #21131J
Matthew Vander Heiden / Frances Diehl / David Sykes / Peggy Hsu
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

Tissue Platform and Machine Learning Algorithm for Drug-Drug Transporter Interaction Discovery

Technology / Case number: #21883J
Robert Langer / Daniel Reker / Vance Soares / Yunhua Shi / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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