Nucleotide Depletion as Differentiation Therapy in the Treatment of Cancer
Invention type: Technology
/
Case number: #21131J
The present disclosure provides methods for inhibiting cell proliferation, inducing differentiation, and inducing replication stress in a cancer cell. The present disclosure also provides methods for treating a cancer in a patient. Various methods of the disclosure include contacting a cancer cell with, or administering to a patient having cancer, an agent that can change the internal baseline ratio of purine:pyrimidine in the cancer cell.
Researchers
Matthew Vander Heiden
/
Peggy Hsu
/
David Sykes
/
Frances Diehl
Departments: David H Koch Institute for Integrative Cancer Res
Technology Areas: Drug Discovery and Research Tools: Cell Interrogation / Therapeutics: Cell Based Therapy
Impact Areas: Healthy Living
-
method of treating cancer with nucleotide therapeutics
United States of America | Published application
License this technology
Interested in this technology? Connect with our experienced licensing team to initiate the process.
Sign up for technology updates
Sign up now to receive the latest updates on cutting-edge technologies and innovations.