Nucleotide Depletion as Differentiation Therapy in the Treatment of Cancer
Invention type: Technology
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Case number: #21131J
The present disclosure provides methods for inhibiting cell proliferation, inducing differentiation, and inducing replication stress in a cancer cell. The present disclosure also provides methods for treating a cancer in a patient. Various methods of the disclosure include contacting a cancer cell with, or administering to a patient having cancer, an agent that can change the internal baseline ratio of purine:pyrimidine in the cancer cell.
Researchers
Departments: David H Koch Institute for Integrative Cancer Res
Technology Areas: Drug Discovery and Research Tools: Cell Interrogation / Therapeutics: Cell Based Therapy
Impact Areas: Healthy Living
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method of treating cancer with nucleotide therapeutics
United States of America | Published application
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