Cellular Backpacks for Drug Delivery Across the Blood-Brain Barrier

Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells can cross the blood-brain barrier while remaining viable after attachment of the functional patch. Functional payloads carried by the patch can include a drug. The patch can include one or more polyelectrolyte multilayers (PEMs).

Researchers

Roberta Polak / Elena Batrakova / Matthew Haney / Yuling Zhao / Natalya Klyachko / Michael Rubner / Robert Cohen

Departments: Center for Materials Science and Engineering, Department of Chemical Engineering
Technology Areas: Biotechnology: Synthetic Biology / Chemicals & Materials: Polymers / Drug Delivery: Vectors & Virus like Particles / Drug Discovery and Research Tools: Cell Lines & Organoids
Impact Areas: Healthy Living

  • synthetically functionalized living cells for targeted drug delivery
    United States of America | Granted | 11,400,114

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