Cellular Backpacks for Drug Delivery Across the Blood-Brain Barrier
Invention type: Technology
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Case number: #18547J
Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells can cross the blood-brain barrier while remaining viable after attachment of the functional patch. Functional payloads carried by the patch can include a drug. The patch can include one or more polyelectrolyte multilayers (PEMs).
Researchers
Roberta Polak
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Elena Batrakova
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Matthew Haney
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Yuling Zhao
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Natalya Klyachko
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Michael F Rubner
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Robert Cohen
Departments: Center for Materials Science and Engineering, Department of Chemical Engineering
Technology Areas: Biotechnology: Synthetic Biology / Chemicals & Materials: Polymers / Drug Delivery: Vectors & Virus like Particles / Drug Discovery and Research Tools: Cell Lines & Organoids
Impact Areas: Healthy Living
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synthetically functionalized living cells for targeted drug delivery
United States of America | Granted | 11,400,114
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