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"Click-Type" Modifications of Peptides via SNAr Reaction of Thiols with Fluorinated Aromatic Molecules

Exclusively Licensed Technology / Case number: #15765
Stephen Buchwald / Chi Zhang / Yekui Zou / Alexander Spokoyny / Bradley L. Pentelute
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living

Somatic Opsins for Single Cell Resolution Optogenetics

Non-Exclusively Licensed Technology, Tangible Property / Case number: #18756TE
Edward Stuart Boyden / Changyang Linghu / Or Shemesh
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
License

End-Modified Poly(b-amino ester)s

Non-Exclusively Licensed Technology / Case number: #12049Q
Robert Langer / Gregory Zugates / Andreas Zumbuehl / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
License

Method for Examining Podocyte Foot Processes in Human Renal Samples Using Conventional Optical Microscopy

Non-Exclusively Licensed Technology, Tangible Property / Case number: #18385TEJ
Edward Stuart Boyden / Octavian Bucur / Andrew Beck / Yongxin Zhao
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials / Sensing & Imaging
Impact Areas: Healthy Living
License

Flow Analysis by Merging of Multiple Integrated Spatial Samplings (FAMMISS)

Exclusively Licensed Technology / Case number: #19546
James Fujimoto / ByungKun Lee / Eric Moult
Technology Areas: Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living

A Hybrid, Vector-Free, Microfluidic Delivery Platform for Engineering Cell Function

Exclusively Licensed Technology / Case number: #17401
Robert Langer / Xiaoyun Ding / Armon Sharei / Klavs F. Jensen
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living

An Automated Computational Framework for the Design of Human-Specific Mechanical Interfaces that Connect a Device to a Biological Body Segment

Exclusively Licensed Technology / Case number: #18446TE
Hugh M Herr / Kevin Moerman / David Sengeh
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Computer Science / Industrial Engineering & Automation
Impact Areas: Healthy Living

An Interchangeable Insert for Ergonomic Interfacing of Finger with Nailfold Imaging Device

Exclusively Licensed Technology / Case number: #21087
Ian Butterworth
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living

Modifications and Coatings to Improve Biocompatibility of Neurological Implants

Exclusively Licensed Technology / Case number: #19323J
Robert Langer / Robert Hevner / Samuel Browd / Brian Hanak / William Shain / Omid Veiseh / Daniel Anderson
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials

Peptide and Protein Modification to Afford Sox-Based Kinase Sensors

Exclusively Licensed Technology / Case number: #12133Q
Barbara Imperiali / Dora Carrico-Moniz / Elvedin Lukovic
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Molecular Determinants of Human Adaptation of H5N1 Influenza A Virus Hemagglutinin

Exclusively Licensed Technology / Case number: #14274
Rahul Raman / Kannan Tharakaraman / Karthik Viswanathan / Ram Sasisekharan
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Method for Oil Production from Bacterial Culture

Non-Exclusively Licensed Technology / Case number: #12971
Anthony Sinskey / Daniel MacEachran / Jason Holder / Kazuhiko Kurosawa / Paolo Boccazzi
Technology Areas: Biotechnology / Energy & Distribution
Impact Areas: Sustainable Future
License

Molecular Design of Antibodies with Enhanced Stability

Non-Exclusively Licensed Technology / Case number: #13229J
Bernhardt Trout / Veysel Kayser / Vladimir Voynov / Bernhard Helk / Naresh Chennamsetty
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

Intracellular Delivery to Red Blood Cells

Exclusively Licensed Technology / Case number: #17754
Klavs F. Jensen / James Abshire / Armon Sharei / Jacquin Niles
Technology Areas: Biotechnology
Impact Areas: Healthy Living

Synthetic Oncolytic LNP-Replicon RNA for Cancer Immunotherapy

Exclusively Licensed Technology / Case number: #21306HJQ
Darrell J Irvine / Noor Momin / Yingzhong Li / Yizhou Dong / Ron Weiss / Karl Dane Wittrup
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living

Light-gated Ion Channels with Fast Kinetics and High Sensitivity

Exclusively Licensed Technology / Case number: #16950TEJ
Gane Wong / Adam Cohen / Daniel Hochbaum / Yongku Cho / Nathan Klapoetke / Edward Stuart Boyden / Brian Chow
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living

Method of Separating Liquid Mixtures in Microsystems - Microdistillation

Non-Exclusively Licensed Technology / Case number: #13334
Klavs F. Jensen / Ryan Hartman / Hemantkumar Sahoo
Technology Areas: Biotechnology / Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Sustainable Future
License

A Dual-Barreled Medical Injector

Exclusively Licensed Technology / Case number: #23529
Kripa K Varanasi / Vishnu Jayaprakash
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living

Enhanced Polypeptide Synthesis by Inline Reagent Pretreatment

Exclusively Licensed Technology / Case number: #17541
Klavs F. Jensen / Alexander Mijalis / Dale Thomas / Mark Simon / Bradley L. Pentelute / Patrick Heider / Andrea Adamo
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials

Directed Evolution of Synthetic Gene Cluster

Exclusively Licensed Technology / Case number: #15653
Christopher Voigt / Michael Smanski / Dehua Zhao
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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