Synthetic Oncolytic LNP-Replicon RNA for Cancer Immunotherapy

Exclusively Licensed

The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.

Researchers

Darrell J Irvine / Noor Momin / Yingzhong Li / Yizhou Dong / Ron Weiss / Karl Dane Wittrup

Departments: David H Koch Institute for Integrative Cancer Res, Department of Biological Engineering, Department of Chemical Engineering
Technology Areas: Biotechnology: Synthetic Biology / Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Nucleic Acids, Vaccines
Impact Areas: Healthy Living

  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Hong Kong | Published application
  • synthetic oncolytic lnp-replicon rna for cancer immunotherapy
    United States of America | Granted | 11,717,548
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    New Zealand | Pending
  • synthetic oncolytic lnp-replicon rna uses for cancer immunotherapy
    United States of America | Published application
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Malaysia | Pending
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Australia | Pending
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Brazil | Pending
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Canada | Published application
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    China | Published application
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Colombia | Published application
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    European Patent Convention | Published application
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Israel | Pending
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    India | Published application
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Japan | Granted | 7,561,134
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Mexico | Published application
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Malaysia | Granted | 0
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    New Zealand | Pending
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Philippines | Pending
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Russian Federation | Granted | 2,809,724
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Saudi Arabia | Pending
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Singapore | Pending
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Thailand | Pending
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Korea (south) | Published application
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    United Arab Emirates | Pending
  • synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
    Japan | Published application

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