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DIAL: Programmable Promoter Editing to Generate Defined, Heritable Setpoints of Gene Expression

Technology / Case number: #25874
Katie Galloway / Mary Ehmann / Yunbeen Bae / Sneha Kabaria
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Fusion Proteins As A Cause For ALS

Technology / Case number: #24280J
Ernest Fraenkel / Ricardo Pinto / Dadi Gao / Michael Talkowski / Allison Dilliott / Spencer Kim / Merit Cudkowicz / James Berry / Tiziana Petrozziello / Vakili Khashayar / Yogindra Raghav / Sali Farhan / Ghazaleh Sadri-Vakili
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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A Signal Inverter Module for RNA Cleavers: Detecting and Evaluating miRNA, Ribozymes, and Ribonucleases

Technology / Case number: #19604
Ron Weiss / Breanna DiAndreth
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Computational Reconfigurable Imaging Spectrometer (CRISP)

Technology / Case number: #19426L
Sumanth Kaushik / Ryan Sullenberger / Adam Milstein / Yaron Rachlin / Charles Wynn
Technology Areas: Agriculture & Food / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living, Sustainable Future
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In-Pipe Leak Detection via Multi-Point Close Proximity Scanning

Technology / Case number: #14570KJ
Kamal Youcef-Toumi / Rached Ben-Mansour / Dimitrios Chatzigeorgiou / Stephen Ho / Sanjay Emani Sarma
Technology Areas: Agriculture & Food / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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Frameshift Suppressor tRNAs for Canonical Amino Acids

Technology / Case number: #21418TREJ
Kevin Esvelt / Ahmed Badran / Erika Alden DeBenedictis
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Advanced Materials
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Channel-less Drip Irrigation Emitter

Technology / Case number: #25861
Amos Winter / Julia Howarth / Aditya Avinash Ghodgaonkar
Technology Areas: Agriculture & Food / Environmental Engineering / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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CRISPR-based Diagnostics for Transplantation Medicine

Technology / Case number: #21752J
James Collins / Michael Kaminski / Leonardo Riella
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
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Daughterless Male Mammals for Population Suppression

Technology / Case number: #21866TE
Kevin Esvelt
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Sustainable Future
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Methods for Identifying and Modulating Co-occurant Cellular Phenotypes

Technology / Case number: #19998R
No Inventor / Ryan King / Jeffrey Van Humbeck / Carly Ziegler / Alex Genshaft / Alex Shalek
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living
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Methods for the Treatment of Trinucleotide Repeat Expansion Disorders Associated with FAN1 activity via Targeting of FAN1 Splice Site Inhibitory Sequences

Technology / Case number: #24829
David Housman / Christopher Ng
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Methods of Enhancing the Survival of Introduced Genes and Organisms

Technology / Case number: #22105TE
Kevin Esvelt / Sarah Vitak
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Predictor of Deletions after Targeted Chromosome Cleavage

Technology / Case number: #21045
David K Gifford / Jonathan Hsu / Max Shen
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living, Connected World
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Formulated, Biodegradable Polymeric Nanoparticles for Nucleic Acid Delivery to Non-Liver Targets

Technology / Case number: #19802
Daniel Anderson / Luke Rhym / Asha Patel / James Kaczmarek / Kevin Kauffman
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Screens for Exploring Biological Functions of Microscale Biological Systems

Technology / Case number: #19737JR
Paul Blainey / Navpreet Ranu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Daniel Anderson / Idris Raji / Jacob Witten / Allen Jiang / Luke Rhym
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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New Ionizable Lipid Library Suitable for Multiple Organ Targeting Derived From High Throughput Combinatorial Synthesis and Screening

Technology / Case number: #23406
Daniel Anderson / Idris Raji / Akiva Gordon / Bowen Li
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Single-Cell RNA Sequencing Using Click-Chemistry

Technology / Case number: #20396
Phillip Sharp / D.B.Jay Mahat
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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In-Pipe Leak Detection System

Technology, Tangible Property / Case number: #19034JC
Kamal Youcef-Toumi / Michael Finn-Henry / Kris Kim / You Wu / Rached Ben-Mansour
Technology Areas: Agriculture & Food / Environmental Engineering / Sensing & Imaging
Impact Areas: Sustainable Future
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Oleogel Drug Delivery Systems for Pediatric Applications

Technology / Case number: #22116J
Robert Langer / Christina Karavasili / Aniket Wahane / Ameya Kirtane / Giovanni Traverso
Technology Areas: Agriculture & Food / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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