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Novel Chimeric Antigen Receptor Signaling Domains Derived via Activity-based Directed Evolution

Technology / Case number: #21116
Michael Birnbaum / Taeyoon Kyung
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Arterial Wall Characterization in Optical Coherence Tomography Imaging

Technology / Case number: #21209
Elazer Edelman / Max Olender / Lambros Anthanasiou
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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A Ribonucleoprotein Approach to Boost the STING Signaling for Cancer Immunotherapy

Technology / Case number: #21216
Jiahe Li / Yanpu He / Paula Hammond
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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MicroRNA-based Logic Gates that Do Not Use Exogenous Proteins

Technology / Case number: #21334
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Synthesis and Anti-cancer Activity of Communesin Alkaloids

Technology / Case number: #21462
Mohammad Movassaghi / Matthew Pompeo / Jaime Cheah
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Synthesis of Potent Epidithiodiketopiperazines Designed for Facile Derivatization

Technology / Case number: #21469
Mohammad Movassaghi / Joshua Payette / Jaime Cheah / Chase Olsson / Tony Scott
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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An Integrated and Automated Electronic System for Point-of-Care Protein Testing

Technology / Case number: #21674
Dan Wu / Joel Voldman
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
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An Electrokinetic-based High-Throughput Concentrator for Cells, Bioparticles, and Molecules

Technology / Case number: #21685
Hyuckjin Kwon / Jongyoon Han
Technology Areas: Agriculture & Food / Biotechnology / Diagnostics
Impact Areas: Healthy Living
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Synthetic Medical Image Generation

Technology / Case number: #21698
Elazer Edelman / Max Olender
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Computer Science / Sensing & Imaging
Impact Areas: Healthy Living
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Optimization of Ventricular Catheters

Technology / Case number: #21751
Thomas Heldt / Lydia Bourouiba / Sungkwon Lee
Technology Areas: Biotechnology
Impact Areas: Healthy Living
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Molecular Memory Retrieval by Position-based Addressing

Technology / Case number: #21829
Tyson Shepherd
Technology Areas: Biotechnology / Chemicals & Materials / Computer Science
Impact Areas: Connected World
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Accurate Genome Editing

Technology / Case number: #21848
Timothy Lu / Shota Nakade
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Carbon Nanoparticles for use as a Vehicle to Target and Treat Macrophages, and Macrophage RNF41 as a Molecule Essential to Switch Macrophage Phenotype

Technology / Case number: #22023
Elazer Edelman / Pedro Melgar Lesmes
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Portable, Precise, Calibration-Free, Rheological Characterization of Fluid Viscoelasticity for Rapid Use

Technology / Case number: #22131
Lydia Bourouiba / Nicole Bustos
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Simultaneous Delivery of Cancer Treatment Programs to Tumor and Immune Cells

Technology / Case number: #22351
Ron Weiss / Jin Huh / Yingzhong Li
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Exhalation Emission Simulator

Technology / Case number: #22626
Lydia Bourouiba / Rishabh Datta / Yongji Wang
Technology Areas: Biotechnology
Impact Areas: Healthy Living
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Compositions of Polypeptides for Subunit Vaccines for SARS-CoV-2

Technology / Case number: #22703
John Love / Neil Dalvie / Sergio Rodriguez
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Method to Simulate Metrics of Vascular Function from Clinical Data

Technology / Case number: #22712
Elazer Edelman / Jonathan Brown / Michael Murphy
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living
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Perfusable Host Microfluidic Endothelial Networks for Spheroid and Organoid Co-culture and Immune Cell Infiltration Studies

Technology / Case number: #22749
Roger Kamm / Huu Tuan Nguyen / Sharon Lee
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Closed-Loop System for Blood Pressure Control

Technology / Case number: #22797
Emery Brown / Taylor Baum
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Computer Science
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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