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Circular, Strained Zymogen

Technology / Case number: #21110J
Ronald Raines / Ian Windsor
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Emboli Detection Methods to Identify Stroke Mechanism or Stroke Risk in Susceptible Adults and Children

Technology, Software / Case number: #21233J
Thomas Heldt / Syed Imaduddin / Kerri LaRovere / Barry Kussman
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living
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Use of Choline Supplementation as Therapy for APOE4-Related Disorders

Technology / Case number: #20957WPJ
Li-Huei Tsai / Yuan-Ta Lin / Julia Bonner / Priyanka Narayan / Greg Sienski
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Advanced Architectures and Operating Principles for Electrochemical Neuro-Modulation

Technology / Case number: #20280J
Daniel Freeman / Matthew Flavin / Jongyoon Han
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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PROTAC Derivatives with Functional Handles for Chemical Conjugation/Modification

Technology / Case number: #20788J
Jeremiah Johnson / Yivan Jiang / Hung Nguyen / Alexandre Detappe / Irene Ghobrial / Michael Agius / Aiden Wang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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A Multimodal Metric for Tracking Nociception Under Anesthesia

Technology / Case number: #20522J
Emery Brown / Riccardo Barbieri / Sandya Subramanian
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living
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Gene Therapy in Mammalian Cells by the use of the Strand Displacement Reaction

Technology / Case number: #21486
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

Anti-Human KLRB1 Monoclonal Antibodies and Uses Thereof

Technology / Case number: #21645J
Kai Wucherpfennig / Byong Ha Kang / Nathan Mathewson / Karl Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Single-Dose Combination Immunotherapy Augments Responses to Checkpoint Blockades for the Treatment of Cancer

Technology / Case number: #21150H
Chensu Wang / Darrell Irvine / Karl Wittrup
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Leveraging Device-arterial Coupling to Determine Cardiac and Vascular State

Technology / Case number: #20558J
Elazer Edelman / Brian Chang / Steven Keller / Sonya Sanat Bhavsar / Noam Josephy / Quing Tan / Ahmad El Katerji
Technology Areas: Biotechnology
Impact Areas: Healthy Living
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Immunostimulatory Nanoparticle Adjuvants

Technology / Case number: #20798HJ
Murillo Silva / Yu Kato / Shane Crotty / Darrell Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Overcoming Emission Photon Scattering in Wide-Field Microscopy

Technology / Case number: #20164P
Christopher Rowlands / Jong Kang Park / Yi Xue / Kalen Berry / Balpreet Ahluwalia / Dushan Wadduwage / Peter So / Elly Nedivi
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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Enhanced Endogenous Recombination for Gene Therapy and Genetic Engineering

Technology / Case number: #20008M
Guoping Feng / Jonathan Wilde / Tomomi Aida / Martin Wienisch / Qiangge Zhang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Eye Drop Positioning Device with Haptic Feedback

Technology / Case number: #25116
Benjamin Lahner / Seung Hyeon Shim / Carly Smith / Jesse George-Akpenyi
Technology Areas: Biotechnology
Impact Areas: Healthy Living
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Split Intein-based Selection for Modified Peptide Binders to SARS-CoV-2 Spike Protein

Technology / Case number: #22502
Christopher Voigt / Emerson Glassey / Andrew King
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Minimally Invasive Electroceutical Catheters

Technology / Case number: #22483J
Ellen Roche / Terry Steele / Manisha Singh
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
License

Low Power Battery and Signaling System

Technology / Case number: #25211J
Carlo Giovanni Traverso / Adam Gierlach / James McRae / Yeseul Jeon / Ian Ballinger / Anantha Chandrakasan
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Communication Systems / Energy & Distribution
Impact Areas: Healthy Living, Connected World
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Medical Recordkeeping Microneedles

Technology / Case number: #24923
Ana Jaklenec / Robert Langer / Maria Kanelli / Jooli Han / Yang Liu / Frederic Durand (he/him/his)
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Programmable Lipid Nanoparticle Delivery via Corona Protein Engineering

Technology / Case number: #25165
Omar Abudayyeh / Jonathan Gootenberg / Cian Schmitt-Ulms / Alisan Kayabolen
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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