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Nucleotide Depletion as Differentiation Therapy in the Treatment of Cancer

Technology / Case number: #21131J
Matthew Vander Heiden / Peggy Hsu / David Sykes / Frances Diehl
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Tissue Platform and Machine Learning Algorithm for Drug-Drug Transporter Interaction Discovery

Technology / Case number: #21883J
Carlo Giovanni Traverso / Yunhua Shi / Vance Soares / Daniel Reker / Robert Langer
Technology Areas: Biomaterials & Bioelectronics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Polymers for Messenger RNA Delivery to the Lung

Technology / Case number: #19314
Kevin Kauffman / James Kaczmarek / Asha Patel / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure-Guided Chemical Modification of Guide RNA and its Applications

Technology / Case number: #19175V
Hao Yin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Gene Delivery Carrier

Technology / Case number: #19091J
Umberto Palmiero / James Kaczmarek / Davide Moscatelli / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Advanced Materials
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Crystalline and Amorphous Formulations Used to Deliver Anti-Fibrotic (and other) Compounds in Conjunction with Implanted Materials (Cells/Devices)

Technology / Case number: #18287J
Joshua Doloff / Shady Farah / Robert Langer / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
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Anti-Zika Virus Antibodies

Technology / Case number: #18525J
Kannan Tharakaraman / Eng Ooi / Kuan Chan / Satoru Watanabe / Subhash Vasudevan / Ram Sasisekharan
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Thin-film Nanocomposite Membranes for Separating Ions and Uncharged Species in Water

Technology / Case number: #24335
Zachary Smith / Gang Han
Technology Areas: Chemicals & Materials / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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Pore Creation Methods in Monolayer Graphene for Membrane Applications

Technology / Case number: #18915J
Jing Kong / Rohit Karnik / Tahar Laoui / Piran Kidambi / Ahmed Ibrahim / Sui Zhang
Technology Areas: Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Advanced Materials
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DNA Based Immobilization for Improved Electrochemical Carbon Dioxide Reduction

Technology / Case number: #23961
Ariel Furst / Gang Fan
Technology Areas: Biotechnology / Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Climate Stabilization, Sustainable Future
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Ionizable Lipids for Messenger RNA Delivery

Technology, Tangible Property / Case number: #24861
Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Thermo-Responsive, Inflammation-Targeting (TRIT) Hydrogel Formulations for Local Drug Delivery in Intestinal Inflammation

Technology / Case number: #19181J
Carlo Giovanni Traverso / Sufeng Zhang / Ashok Kakkar / Joshua Korzenik / Robert Langer
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Brice Curtin / Jasmin Kruell / Catherine Henry / Sebastian Pomplun / Christina Woo / Chia-fu Chang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Macro-Devices for Ultra-Long Residence and Large-Dose Drug Delivery in Stomach

Technology / Case number: #20938JQ
Carlo Giovanni Traverso / Robert Langer / Sahab Babaee / Simo Pajovic / Jiuyun Shi
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Systems for Electrical Stimulation

Technology / Case number: #20707JQ
Carlo Giovanni Traverso / Alex Abramson / David Dellal / Robert Langer
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Retrieval Systems for Gastric Resident Systems

Technology / Case number: #20382JQ
Carlo Giovanni Traverso / Malvika Verma / Niclas Roxhed / Feyisope Eweje / Macy Castaneda / Robert Langer
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Pooled Screening Identifies Genomic Features (Biomarkers) Modulating Nanoparticle-Cell Interactions

Technology / Case number: #22785J
Angela Koehler / Natalie Boehnke / Joelle Straehla / Paula Hammond
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Single-shot 16-fold Expansion Microscopy (16ExM)

Technology / Case number: #24859MH
Edward Boyden / Laura Kiessling / Tay Won Shin / Shiwei Wang / Yixi Liu / Harley Yoder
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Spatially Localized Gene Delivery of Adeno-Associated Viruses

Technology / Case number: #25055
Polina Anikeeva / Keisuke Nagao
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Lipid Anchorage of Cytokines onto Layer-by-Layer Nanoparticles

Technology / Case number: #25070H
Ivan Susin Pires / Darrell Irvine / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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