Macro-Devices for Ultra-Long Residence and Large-Dose Drug Delivery in Stomach

This invention presents residence devices for long-term delivery of therapeutic compounds and/or sensing relevant in vivo parameters. The device comprises interconnected links with flexible hinges, allowing it to be deformed for easy introduction and then expanded in a desired location, such as the stomach. Addressing medication non-adherence, the device incorporates a coupling mechanism that weakens or disassembles when exposed to a temperature greater than a threshold, offering controlled release and potentially revolutionizing the administration of complex pharmaceutical regimens.