Systems for Electrical Stimulation

This invention introduces self-righting articles, particularly capsules for subject administration, designed to autonomously orient themselves relative to tissue surfaces. Addressing challenges in maximizing drug delivery and mucosa interaction, the articles comprise tissue-engaging surfaces with self-righting behavior, leveraging specific shapes and density distributions. By incorporating tissue-interfacing components with electrically conductive portions for communication with tissue, these articles provide an innovative solution for targeted electrical stimulation in the gastrointestinal tract, presenting advancements in drug delivery and therapeutic interventions without the need for surgery or invasive procedures.