Thermo-Responsive, Inflammation-Targeting (TRIT) Hydrogel Formulations for Local Drug Delivery in Intestinal Inflammation

This technology introduces innovative solutions for targeted drug delivery, particularly focusing on thermoresponsive hydrogel polymers. These formulations incorporate thermoresponsive hydrogel polymers containing releasable therapeutic agents, offering a unique blend of characteristics, including mechanical strength, biocompatibility, thermal responsiveness, and precise drug delivery configurations. The compositions can include a sol-to-gel transition system under physiological conditions, comprising nanoparticles and thermoresponsive polymers with attached ligands. In the medical context, this technology addresses the need for improved drug delivery in conditions such as Ulcerative Colitis, ensuring more effective and precise treatment.