Methods for the Production of Porous Scaffolds Comprising Multiple Layers with Distinct Characteristics

A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.

Researchers

Lorna Gibson / Zachary Wissner-Gross / William Bonfield / Andrew Lynn / Brendan Harley / Ioannis Yannas

Departments: Department of Materials Science and Engineering, Department of Mechanical Engineering
Technology Areas: Biotechnology: Synthetic Biology / Chemicals & Materials: Composites
Impact Areas: Healthy Living

  • biomaterial
    India | Published application
  • methods for the production of porous scaffolds comprising multiple layers with distinct characteristics
    Singapore | Published application
  • biomaterial
    Japan | Published application
  • biomaterial
    Korea (south) | Published application
  • biomaterial
    United States of America | Granted | 8,318,902

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