Highly Parallel Profiling of Enzymes In Vivo Using Mass-Encoded Substrate Libraries

Non-Exclusively Licensed

The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention.

Researchers

Sangeeta Bhatia / Gabriel Kwong / Geoffrey Von Maltzahn

Departments: Health Sciences and Technology Program
Technology Areas: Biotechnology: Sensors & Monitoring / Diagnostics: Assays / Therapeutics: Proteins & Antibodies
Impact Areas: Healthy Living

  • methods and products for in vivo enzyme profiling
    United States of America | Granted | 11,549,951
  • methods and products for in vivo enzyme profiling
    United States of America | Granted | 8,673,267
  • methods and products for in vivo enzyme profiling
    European Patent Convention | Granted | 2,403,964
  • methods and products for in vivo enzyme profiling
    Japan | Granted | 6,067,225
  • methods and products for in vivo enzyme profiling
    United States of America | Granted | 9,970,941
  • methods and products for in vivo enzyme profiling
    United States of America | Granted | 10,883,998
  • methods and products for in vivo enzyme profiling
    United States of America | Granted | 11,703,510
  • methods and products for in vivo enzyme profiling
    European Patent Convention | Published application
  • methods and products for in vivo enzyme profiling
    Liechtenstein | Granted | 2,403,964
  • methods and products for in vivo enzyme profiling
    United Kingdom | Granted | 2,403,964

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