Highly Parallel Profiling of Enzymes In Vivo Using Mass-Encoded Substrate Libraries
                                                                                        
                                    Non-Exclusively Licensed
                                
                            
                            
                            
                                                    
                    
                    
                                                                            Invention type: Technology
                                    
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                                                                            Case number: #13062
                                                                    
                                The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention.
Researchers
                            
    
    Sangeeta Bhatia
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    Gabriel Kwong
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    Geoffrey Von Maltzahn
                        
                    
                                        Departments: Health Sciences and Technology Program
                                    
                                
                                                                    
                                        Technology Areas: 	Biotechnology: Sensors & Monitoring  / Diagnostics: Assays  / Therapeutics: Proteins & Antibodies 
                                    
                                
                                                                    
                                        Impact Areas: Healthy Living
                                    
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            methods and products for in vivo enzyme profiling
 United States of America | Granted | 11,549,951
- 
            methods and products for in vivo enzyme profiling
 United States of America | Granted | 8,673,267
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            methods and products for in vivo enzyme profiling
 European Patent Convention | Granted | 2,403,964
- 
            methods and products for in vivo enzyme profiling
 Japan | Granted | 6,067,225
- 
            methods and products for in vivo enzyme profiling
 United States of America | Granted | 9,970,941
- 
            methods and products for in vivo enzyme profiling
 United States of America | Granted | 10,883,998
- 
            methods and products for in vivo enzyme profiling
 United States of America | Granted | 11,703,510
- 
            methods and products for in vivo enzyme profiling
 European Patent Convention | Published application
- 
            methods and products for in vivo enzyme profiling
 Liechtenstein | Granted | 2,403,964
- 
            methods and products for in vivo enzyme profiling
 United Kingdom | Granted | 2,403,964
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