DNA Virus Launched RNA Replicon System (VREP) for Prolonged and High Level Expression of Transgenes with High Precision Controls
Invention type: Technology
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Case number: #20866
Provided herein, in some aspects, are antibody expression systems comprising DNA launched RNA replicons for high level antibody expression. In some embodiments, the antibody is a therapeutic antibody. In some embodiments, the antibody is an immune check point inhibitor. Methods of using the antibody expression system for treating diseases (e.g., cancer) are also provided.
Researchers
Ron Weiss
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Jacob Becraft
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Jin Huh
Departments: Department of Biological Engineering
Technology Areas: Biotechnology: Synthetic Biology / Drug Delivery: Vectors & Virus like Particles / Drug Discovery and Research Tools: Genomics & Proteomics / Therapeutics: Proteins & Antibodies
Impact Areas: Healthy Living
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dna launched rna replicon system (drep) and uses thereof
United States of America | Published application
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