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In Vitro Human Blood Brain Barrier

Technology / Case number: #19918P
Li-Huei Tsai / Joel Blanchard
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Methods for the Treatment of Trinucleotide Repeat Expansion Disorders Associated with FAN1 activity via Targeting of FAN1 Splice Site Inhibitory Sequences

Technology / Case number: #24829
David Housman / Christopher Ng
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Methods for Improving Cross-Ancestry Transferability in Predicting Polygenic Phenotypes from Genetic Variation

Technology / Case number: #24858
Manolis Kellis / Yosuke Tanigawa
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Novel Peptides Capable of Altering NK Cell Activity

Technology / Case number: #24321JQ
Michael Birnbaum / Timo Ruckert / Chiara Romagnani / Brooke Huisman
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Bioelectronic Devices to Support Transplanted Cells in Vivo for Encapsulated Cell Therapies

Technology / Case number: #23269J
Robert Langer / Nima Khatib / Matt Bochenek / Siddharth Krishnan / Suman Bose / Daniel Anderson
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Energy & Distribution / Therapeutics
Impact Areas: Healthy Living
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Apparatus for Forming and Processing Arrangements of Embedded Droplets

Technology / Case number: #21603JDE
Saif Khan / Arif Nelson / Patrick Doyle
Technology Areas: Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Anti-Fouling Coatings Designed via Full Spectral Hamaker Constant Minimization

Technology / Case number: #21604
Michael Short / Minh Dinh / Cigdem Toparli / Max Carlson / Bilge Yildiz
Technology Areas: Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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Hydrogen Resistance Coatings via Hydrogen Diffusivity Minimization Based on Computationally Engineering Intrinsic and Extrinsic Defect Structure

Technology / Case number: #21800
Bilge Yildiz / Minh Dinh / Cigdem Toparli
Technology Areas: Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Advanced Materials
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Dissolvable Microcarriers for Adherent Cell Culture

Technology / Case number: #22052JDE
Krystyn Van Vliet / Ee Xien Ng
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Advanced Materials
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Gradient-Morph LiCoO2 Single Crystals with Stabilized Energy-Density above 3400 Wh/L in Full-Cells

Technology / Case number: #22063
Ju Li / Yimeng Huang / Zhi Zhu
Technology Areas: Chemicals & Materials / Energy & Distribution
Impact Areas: Sustainable Future
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Methods of Enhancing the Survival of Introduced Genes and Organisms

Technology / Case number: #22105TE
Kevin Esvelt / Sarah Vitak
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Planetary Centrifugal Deagglomeration by Transient Molten Salts for the Synthesis or Recycling of Single-Crystalline Battery Cathodes

Technology / Case number: #24878J
Ju Li / Jaephil Cho / Moonsu Yoon / Yanhao Dong
Technology Areas: Chemicals & Materials / Energy & Distribution
Impact Areas: Sustainable Future
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Methane Upgrade to Ethane and Ethylene within Ceramic Membrane Reactors

Technology / Case number: #22915
Ahmed Ghoniem / Georgios Dimitrakopoulos / Bilge Yildiz
Technology Areas: Chemicals & Materials
Impact Areas: Connected World, Advanced Materials
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Genotype-Directed Local Delivery of Targeted Therapeutics at the Tumor Margin

Technology / Case number: #19863J
Robert Langer / Ganesh Shankar / Daniel Cahill / Ameya Kirtane / Giovanni Traverso
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Formulated, Biodegradable Polymeric Nanoparticles for Nucleic Acid Delivery to Non-Liver Targets

Technology / Case number: #19802
Daniel Anderson / Luke Rhym / Asha Patel / James Kaczmarek / Kevin Kauffman
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Screens for Exploring Biological Functions of Microscale Biological Systems

Technology / Case number: #19737JR
Paul Blainey / Navpreet Ranu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Daniel Anderson / Idris Raji / Jacob Witten / Allen Jiang / Luke Rhym
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Single-Cell RNA Sequencing Using Click-Chemistry

Technology / Case number: #20396
Phillip Sharp / D.B.Jay Mahat
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Diagnosis of Malignancy Using Developmental Relationships and Machine Learning

Technology / Case number: #23356
Salil Garg / Enrico Moiso
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Bioinspired Design of Self-Adjuvanted C3d-Fusion SARS-CoV-2 mRNA Vaccines

Technology / Case number: #23326
Robert Langer / Allen Jiang / Bowen Li / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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