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Thiol-yne Mediated Synthesis of Multi-Tailed Lipids for siRNA Delivery

Technology / Case number: #15846
Robert Langer / Akinleye Alabi / Kevin Love / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Risk-Rating Framework for Mobile Applications

Technology / Case number: #17077L
Praveen Sharma / Alan Keith / Robert Shaw / Ramesh Ramachandran / Pierre Trepagnier / Michael Beynon / Joshua Haines / Jeff Gottschalk / Daniel Souza / Evan Fiore
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML)
Impact Areas: Connected World
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Reversible Covalent Modification for Improving Protein Delivery

Technology / Case number: #16581HQ
Darrell J Irvine / Li Tang
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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2.5D Cartoon Models

Technology, Software / Case number: #14391
Fredo Durand (he/him/his) / Alec Rivers
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML)
Impact Areas: Connected World
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Method for Predicting Patient Outcomes from a Quasi-Periodic Patient Signal

Technology / Case number: #16302
John Guttag / Yun Liu / Collin M Stultz
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science
Impact Areas: Healthy Living
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Generalizable End-To-End Autonomous Driving with Multi-Modal Foundation Models

Technology / Case number: #25658J
Daniela Rus / Alaa Maalouf / Wei Xiao / Tsun-Hsuan Wang / Yutong Ban / Alexander Amini / Sertac Karaman / Guy Rosman
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Industrial Engineering & Automation
Impact Areas: Uncharted Frontiers, Connected World
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DNA Instructional Model

Technology / Case number: #17291
J. Kim Vandiver / Kathleen Mead Vandiver / Bethany Lemanski
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Self-Assembled (Poly-(L-Glutamic Acid-PEG-Drug)-PLGA Micelles for Multistage Nanoparticle Delivery System

Technology / Case number: #14877J
Moungi G Bawendi / Dai Fukumura / Cliff Wong / Rakesh K. Jain
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Develop New Lethal Mutagens for Viral Diseases

Technology / Case number: #16089
John M Essigmann / Katherine Silvestre / Deyu Li
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Algorithm for Navigation of an Autonomous Unmanned Aerial Vehicle Using Levy Flight and Simplex Minimization

Technology / Case number: #16529L
Charles Coldwell / Michael Park
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Sensing & Imaging
Impact Areas: Connected World
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Ligand-Inducible Post-Transcriptional Gene Regulation Using Protein-Binding RNA Aptamers

Technology / Case number: #13998J
Brian Belmont / Michael Marletta / Jacquin Niles / Stephen Goldfless
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Dendrimer and Peptide Based Excipients for the Attenuation of Protein Aggregation

Technology / Case number: #14184
Bernhardt Trout / Diwakar Shukla / Curtiss Schneider
Technology Areas: Chemicals & Materials / Industrial Engineering & Automation / Therapeutics
Impact Areas: Healthy Living
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The Design of DNA-scaffolded Subunit Vaccines for Enhanced Germinal Center Responses in HIV Vaccination

Technology / Case number: #25982H
Darrell J Irvine / Anna Romanov / Grant Knappe / Mark Bathe
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Advanced Materials
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Genomic Insertion of Large Cargo with Engineered Retro Elements

Technology / Case number: #23248
Omar Abudayyeh / Justin Lim / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Method for Summarizing Textual Material

Technology / Case number: #17433
Patrick Winston
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML)
Impact Areas: Connected World
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Tissue Specific Delivery of Interfering RNA

Technology / Case number: #13947H
Sangeeta Bhatia / Yin Ren
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Peptide Nucleic Acid Functionalized Hydrogel Microneedles for Sampling and Detection of Interstitial Fluid Nucleic Acids

Technology / Case number: #21359HJ
Darrell J Irvine / Dana Al Sulaiman / Sylvain Ladame / Yin Hao Chang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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3D AI Processor

Technology / Case number: #25102L
Bill Song
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML)
Impact Areas: Uncharted Frontiers
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Development of a Platform to Noninvasively Image Car T Cells

Technology / Case number: #25905J
Michael Hemann / Julia Froese / Ali Salehi / Taha Rakhshandehroo / Jennifer Rowley / Mohammad Rashidian
Technology Areas: Biotechnology / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Biomarkers Derived from Neurophysiological Computational Modeling

Technology / Case number: #18088L
Thomas Quatieri / Joseph Perricone / Gregory Ciccarelli / Jim Williamson / Daryush Mehta / Brian Helfer / Christopher Smalt / Jeffrey Palmer / Satrajit Ghosh
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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