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Non-Fibrotic Implantable Devices on Diverse Organs

Technology / Case number: #24648
Xuanhe Zhao / Jue Deng / Jingjing Wu / Hyunwoo Yuk
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials
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System and Methods for Noninvasive Point-of-Care Intracranial Pressure, Intracranial Compliance, and Cerebrovascular Resistance Measurement

Technology / Case number: #24678
Charles Sodini / Syed Imaduddin / Thomas Heldt
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Preferential Crystallization of fullrAAVs in a Hanging Drop Crystallizer as an Alternative Method for Downstream Purification of rAAV-based Gene Therapies

Technology / Case number: #24870
Anthony Sinskey / Vivekananda Bal / Moo Sun Hong / Stacy Springs / Richard D Braatz / Paul Barone
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Minimally Invasive Electroceutical Catheters

Technology / Case number: #22483J
Ellen Roche / Manisha Singh / Terry Steele
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Stable and Efficient Cell Surface Coupling of Nanoparticles

Technology / Case number: #17836HQ
Darrell J Irvine / Li Tang / Yiran Zheng
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Hydrogel Components Including Narrowly Distributed Multi-Armed Polyethyleneglycol

Technology / Case number: #17843J
Elazer R Edelman / Kenichiro Nakamoto / Hiroki Yoshioka / Yuji Yamamoto / Hyun Seok Song / Natalie Artzi
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials
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Hyperlactatemia Prediction

Technology / Case number: #18128J
George Verghese / Max Dunitz / Michael Filbin / Thomas Heldt / Andrew Reisner
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics / Computer Science
Impact Areas: Healthy Living
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Tandem Peptide Approaches for Delivery to Gram-Negative Bacteria

Technology / Case number: #19017H
Sangeeta Bhatia / Leslie Chan / Ester Kwon
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Darrell J Irvine / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Strong Adhesion of Wet Conducting Polymers on Diverse Substrates

Technology / Case number: #21093
Xuanhe Zhao / Akihisa Inoue / Hyunwoo Yuk
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials
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MicroRNA-based Logic Gates that Do Not Use Exogenous Proteins

Technology / Case number: #21334
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Darrell J Irvine / Masanori Okaniwa / Eric Dane
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Carbon Nanoparticles for use as a Vehicle to Target and Treat Macrophages, and Macrophage RNF41 as a Molecule Essential to Switch Macrophage Phenotype

Technology / Case number: #22023
Elazer R Edelman / Pedro Melgar Lesmes
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Portable, Precise, Calibration-Free, Rheological Characterization of Fluid Viscoelasticity for Rapid Use

Technology / Case number: #22131
Lydia Bourouiba / Nicole Bustos
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Control Replication and Transcription of Self-Replicating RNA in Responses to Small Molecule TMP

Technology / Case number: #22331H
Darrell J Irvine / Parisa Yousefpour / Jan Lonzaric / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Catheter for Intracardiac 3D Bioprinting

Technology / Case number: #22338J
Brett E Bouma / Markus Horvath / Sophie Wang / Milen Shishkov / Victor Damptey / Connor Verheyen / Keegan Mendez / Ellen Roche / Sebastien Uzel / Jennifer Lewis
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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M13 Bacteriophage with a High Cysteine Content and Genetically Engineerable Hydrogels

Technology / Case number: #22369
Angela Belcher / Nimrod Heldman / William Records
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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A Closed-Loop System for Blood Pressure Control

Technology / Case number: #22797
Emery N Brown / Taylor Baum
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Computer Science
Impact Areas: Healthy Living
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Fusion Capsid Therapy for COVID-19 and Applies to Other Viruses: Universal "Dominant" Antiviral to Prevent Virus Evolution and Future Pandemics (DNA/RNA/Protein)

Technology, Tangible Property / Case number: #22801MH
Robert Langer / Bowen Li / Yong Qian / Alexi Choueiri / Edward Stuart Boyden / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Interfacial Bioconjugation on Emulsion Droplets

Technology / Case number: #20314
Timothy Manning Swager / Qifan Zhang
Technology Areas: Chemicals & Materials / Drug Delivery / Sensing & Imaging
Impact Areas: Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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