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Engineering a Swine Macro-Organ Colorectal Cancer Platform to Combat Transport-Induced Chemotherapy Resistance

Technology / Case number: #22864JQ
Robert Langer / Daniel Reker / Vance Soares / Yunhua Shi / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Cellular Backpacks for Drug Delivery Across the Blood-Brain Barrier

Technology / Case number: #18547J
Robert Cohen / Natalya Klyachko / Yuling Zhao / Matthew Haney / Elena Batrakova / Roberta Polak / Michael F Rubner
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Oleogel Drug Delivery Systems for Pediatric Applications

Technology / Case number: #22116J
Robert Langer / Christina Karavasili / Aniket Wahane / Ameya Kirtane / Giovanni Traverso
Technology Areas: Agriculture & Food / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Machine Learning for the Design of Cancer Vaccine Adjuvants

Technology / Case number: #21680J
Robert Langer / Netra Kamat / Hyunjoon Kim / Lewis Scott Jones / Daniel Reker / Ameya Kirtane / Giovanni Traverso
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Nucleotide Depletion as Differentiation Therapy in the Treatment of Cancer

Technology / Case number: #21131J
Matthew Vander Heiden / Frances Diehl / David Sykes / Peggy Hsu
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Tissue Platform and Machine Learning Algorithm for Drug-Drug Transporter Interaction Discovery

Technology / Case number: #21883J
Robert Langer / Daniel Reker / Vance Soares / Yunhua Shi / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Derivation of Enteroendocrine Cells and Insulin Expressing Cells

Technology / Case number: #18445J
Robert Langer / Xiaolei Yin / Jeffrey Michael Karp
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Crystalline and Amorphous Formulations Used to Deliver Anti-Fibrotic (and other) Compounds in Conjunction with Implanted Materials (Cells/Devices)

Technology / Case number: #18287J
Robert Langer / Shady Farah / Joshua Doloff / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Compositions Systems and Methods for Generating Inner Ear Hair Cells for Treatment of Hearing Loss

Technology / Case number: #17900J
Robert Langer / Nitin Joshi / Xiaolei Yin / Jeffrey Michael Karp
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Implantable Devices and Methods for Evaluation of Active Agents

Technology / Case number: #17867J
No Inventor / John Santini / Oliver Jonas / Jason Fuller / Robert Tepper
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Anti-Zika Virus Antibodies

Technology / Case number: #18525J
Ram Sasisekharan / Subhash Vasudevan / Satoru Watanabe / Kuan Chan / Eng Ooi / Kannan Tharakaraman
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Ionizable Lipids for Messenger RNA Delivery

Technology, Tangible Property / Case number: #24861
Daniel Anderson / Idris Raji / Jacob Witten
Technology Areas: Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Thermo-Responsive, Inflammation-Targeting (TRIT) Hydrogel Formulations for Local Drug Delivery in Intestinal Inflammation

Technology / Case number: #19181J
Robert Langer / Joshua Korzenik / Ashok Kakkar / Sufeng Zhang / Giovanni Traverso
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Chimeric Degraders of Cyclin Dependent Kinase 9 with Potential Use for Cancer Therapy

Technology / Case number: #22028
Angela Koehler / Mohammed Toure / Florian Kabinger / Julie Urgiles / Andre Richters
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Macro-Devices for Ultra-Long Residence and Large-Dose Drug Delivery in Stomach

Technology / Case number: #20938JQ
Robert Langer / Jiuyun Shi / Simo Pajovic / Sahab Babaee / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Systems for Electrical Stimulation

Technology / Case number: #20707JQ
Robert Langer / David Dellal / Alex Abramson / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Hybrid Materials with Living Cells and Tough Hydrogels

Technology / Case number: #18548
Timothy K Lu / Tzu-Chieh Tang / Xinyue Liu / Eleonore Tham / Xuanhe Zhao
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Retrieval Systems for Gastric Resident Systems

Technology / Case number: #20382JQ
Robert Langer / Macy Castaneda / Feyisope Eweje / Niclas Roxhed / Malvika Verma / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Pooled Screening Identifies Genomic Features (Biomarkers) Modulating Nanoparticle-Cell Interactions

Technology / Case number: #22785J
Paula Hammond / Joelle Straehla / Natalie Boehnke / Angela Koehler
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Lipid Anchorage of Cytokines onto Layer-by-Layer Nanoparticles

Technology / Case number: #25070H
Darrell J Irvine / Ivan Pires / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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