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Synergisms between Small Molecule Boosters and LNP Formulations Uncovered using High Throughput Screening and Machine Learning

Technology / Case number: #26199J
Giovanni Traverso / Deepak Subramanian / Rajib Dey / Ameya Kirtane
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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LNP Automation Screening System

Technology / Case number: #26217
Robert Langer / Zhiling Zheng / Xin Yang / Linzixuan Rhoda Zhang / Ana Jaklenec
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Lipid-Like Materials for Applications in siRNA Delivery

Technology / Case number: #15420
Robert Langer / Joseph Dorkin / Yunlong Zhang / Arturo Vegas / Kathryn Whitehead / Daniel Anderson
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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2-Aminoindole-Class Antimalarials

Technology / Case number: #14097BJ
Jon Clardy / Elyse Bourque / Yibin Xiang / Renato Skerlj / Edmund Sybertz / Joseph Cortese / Mary Lynn Baniecki / Roger Wiegand / Dyann Wirth / Cassandra Celatka / Sameer Urgaonkar / Ralph Mazitschek
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Hydrophobic Polycationic Coatings That Inhibit Biofilm Formation on Orthopedic Implants and Support Healing During Infection in Sheep

Technology / Case number: #15031J
Alexander Klibanov / Suzanne Stewart / Thomas Schaer / Bryan Hsu
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials
Impact Areas: Healthy Living
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Programmable Insertion Approaches Via Reverse Transcriptase Recruitment

Technology / Case number: #23685
Omar Abudayyeh / Kaiyi Jiang / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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1,3,5-triazinane-2,4,6-trione (TNT) Derivatives and Uses Thereof

Technology / Case number: #15446
Robert Langer / Hao Yin / Akinleye Alabi / Joseph Dorkin / Ahmed Eltoukhy / Yizhou Dong / Delai Chen / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Heterocycle-Modified Quinolines for Fluorescence-Based Protein Kinase Sensing

Technology / Case number: #13876
Barbara Imperiali / Juan Gonzalez Vera / Elvedin Lukovic
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Compositions and Methods to Deliver RNA to Extracellular Matrix Producing Cells

Technology / Case number: #25390J
Daniel Anderson / Dennis Shi / Theresa Raimondo / Sho Toyonaga
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Olfactory Receptor-Based Devices

Technology / Case number: #12776TE
Shuguang Zhang / Liselotte Kaiser / Joanke (Johanna) Bikker Graveland / Brian Cook / Andreas Mershin / Manu Prakash / David Kong / Yael Maguire
Technology Areas: Biotechnology / Chemicals & Materials / Computer Science / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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SNAPPLE - Sequencing-Mediated Numerical Analysis of Parallel Proximity Ligation Events

Technology / Case number: #13615B
Andreas Gnirke / Daniel Aird / Erez Lieberman
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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A Novel Injectable Thiol-Acrylate Poly(ethylene Glycol) Hydrogel for Sustained Release of Methylprednisolone Sodium Succinate

Technology / Case number: #14439J
Robert Langer / Jonathan Slotkin / Francis Reynolds / Timothy O'Shea / Daniel Siegwart / Christopher Pritchard / Eric Woodard / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Translocation of Non-Natural Chemical Entities Through Anthrax Protective Antigen Pore

Technology / Case number: #15639J
Bradley L. Pentelute / R. Collier / Gizem Akcay / Jingjing Ling / Amy Rabideau / Xiaoli Liao
Technology Areas: Computer Science / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Novel Glucose-Responsive Insulin Formulations Using Chemically Modified Insulin Derivatives and Non-Covalent Insulin-Binding Molecules

Technology / Case number: #15976J
Robert Langer / Rosemary Kanasty / Matthew Webber / Kun Xue / Hung-Chieh (Danny) Chou / Benjamin Tang / Yunlong Zhang / Yair Levi / Arturo Vegas / Daniel Anderson
Technology Areas: Chemicals & Materials / Computer Science / Therapeutics
Impact Areas: Healthy Living
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Self Assembled RSV Nanoparticle Vaccines

Technology / Case number: #16549
Ram Sasisekharan / Aditya Raguram / Vidya Subramanian
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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sMutants of Channelrhodopsins with Altered Ion Selectivity

Technology / Case number: #16934TE
Edward Stuart Boyden / Fei Chen / Yongku Cho / Amy Chuong / Nathan Klapoetke
Technology Areas: Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living
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A Novel Multiplexed Inertial Focusing Microfiltration System for Intra-Operative Blood Salvage Autotransfusion

Technology / Case number: #17212DJE
Jongyoon Han / Kah Ping Andy Tay / Majid Ebrahimi Warkiani / Lidan Wu / Guofeng Guan / Chwee-Teck Lim
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Ultrasound-Mediated Gastrointestinal Drug Delivery

Technology / Case number: #17807JQ
Robert Langer / Carl Schoellhammer / Baris Polat / Giovanni Traverso / Avraham Schroeder / William Brugge / Daniel Blankschtein
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Reversible and Ratiometric Sensing using Nanocrystals

Technology / Case number: #11693
Moungi G Bawendi / Rebecca Somers / Preston Snee / Daniel Nocera
Technology Areas: Biotechnology / Diagnostics / Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Colon Delivery Platform for Constipation Treatment

Technology / Case number: #20570JQ
Robert Langer / Christoph Winfried Johannes Steiger / Joshua Korzenik / Giovanni Traverso
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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