Barcoded Combinatorial Genetic Screening with CRISPR-CAS
Exclusively Licensed
Invention type: Technology
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Case number: #17251
Described herein are methods and compositions that enable rapid generation of high-order combinations of genetic elements comprising a CRISPR guide sequence and a scaffold sequence, and a barcode for rapid identification of the combination of genetic elements encoded within a single cell or a pooled population. Also described herein compositions of inhibitors of epigenetic genes and methods for reducing cell proliferation and/or treating cancer.
Researchers
Timothy K Lu
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Ching Gee (Gigi) Choi
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Alan Siu Lun Wong
Departments: Department of Biological Engineering
Technology Areas: Biotechnology: Biomanufacturing, DNA & RNA Editing / Therapeutics: Cell Based Therapy, Nucleic Acids
Impact Areas: Healthy Living
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massively parallel combinatorial genetics for crispr
United States of America | Published application -
massively parallel combinatorial genetics for crispr
Taiwan | Granted | 0 -
massively parallel combinatorial genetics for crispr
Hong Kong | Granted | 0 -
massively parallel combinatorial genetics for crispr
China | Granted | 0 -
massively parallel combinatorial genetics for crispr
Japan | Granted | 6,788,584 -
massively parallel combinatorial genetics for crispr
European Patent Convention | Granted | 3,212,789 -
massively parallel combinatorial genetics for crispr
Switzerland | Granted | 3,212,789 -
massively parallel combinatorial genetics for crispr
Germany | Granted | 3,212,789 -
massively parallel combinatorial genetics for crispr
France | Granted | 3,212,789 -
massively parallel combinatorial genetics for crispr
United Kingdom | Granted | 3,212,789 -
massively parallel combinatorial genetics for crispr
Denmark | Granted | 3,212,789 -
massively parallel combinatorial genetics for crispr
Liechtenstein | Granted | 3,212,789 -
massively parallel combinatorial genetics for crispr
Italy | Granted | 3,212,789 -
massively parallel combinatorial genetics for crispr
Netherlands | Granted | 3,212,789
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